Cheng Xuan, Cheng Wei-Bo, Yan Hao, Zhang Su-Cai, Wang Yu
The Chengdu Municipal Sixth People's Hospital, Chengdu 610051, China.
Zhongguo Zhong Yao Za Zhi. 2008 Feb;33(3):300-2.
To study the preventing effects of procyanidins (PC) on selenite cataract in rats and the time-effect relationship.
Forty five SD rats were divided into three groups: control, model and experiment groups. The rats in the experiment group were fed additionally with the PC by 80 mg x kg(-1) when they were supplied the equal selenite with the model group. Five rats of each group were regularly sacrificed by bleeding from femoral artery at sixth, eleventh, sixteenth day and the level of malondialdehyde (MDA), superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) of all lenses was measured.
Compared with the model group, the level of the MDA in the experiment group at the eleventh day and the sixteenth day greatly decreased (P < 0.01). At the sixteenth day the level of the SOD and GSH-Px had an increase (P < 0.01), which showed its anti-oxygenation.
PC indicated the obvious inhibition in the development of the rat cataract. The treatment period was recommended at least for fifteen days.
研究原花青素（PC）对大鼠亚硒酸盐性白内障的预防作用及其时效关系。
将45只SD大鼠分为对照组、模型组和实验组。实验组大鼠在与模型组给予等量亚硒酸钠的同时，额外给予80mg·kg⁻¹的PC。每组分别于第6天、第11天、第16天定期从股动脉放血处死5只大鼠，检测所有晶状体中丙二醛（MDA）、超氧化物歧化酶（SOD）和谷胱甘肽过氧化物酶（GSH-Px）的水平。
与模型组相比，实验组在第11天和第16天的MDA水平显著降低（P<0.01）。在第16天，SOD和GSH-Px水平升高（P<0.01），显示出其抗氧化作用。
PC对大鼠白内障的发展有明显抑制作用。建议治疗期至少为15天。
