美国儿童及青少年人群中人类疱疹病毒8型血清阳性率

Human herpesvirus 8 seroprevalence among children and adolescents in the United States.

作者信息

Anderson Lesley A, Li Yan, Graubard Barry I, Whitby Denise, Mbisa Georgina, Tan Sylvia, Goedert James J, Engels Eric A

机构信息

Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.

出版信息

Pediatr Infect Dis J. 2008 Jul;27(7):661-4. doi: 10.1097/INF.0b013e3181691740.

DOI:10.1097/INF.0b013e3181691740

PMID:18536622

Abstract

We measured human herpesvirus-8 antibodies (K8.1 and orf73 enzyme immunoassays) in 4166 children, aged 6-17 years, in a U.S. cross-sectional survey. Forty-six were K8.1 seropositive (weighted seroprevalence: 1.1%) and 20 were orf73 seropositive (weighted seroprevalence 0.4%). K8.1 seropositivity was associated with asthma (odds ratio: 6.3; 95% confidence interval: 2.4-16.9) and hay fever (3.5; 1.1-11.0), and there were borderline associations with measures of crowding and low socioeconomic status.

摘要

在美国的一项横断面调查中，我们对4166名6至17岁的儿童进行了人类疱疹病毒8型抗体检测（采用K8.1和orf73酶免疫测定法）。46名儿童K8.1血清学呈阳性（加权血清阳性率：1.1%），20名儿童orf73血清学呈阳性（加权血清阳性率0.4%）。K8.1血清学阳性与哮喘相关（比值比：6.3；95%置信区间：2.4 - 16.9）以及花粉症相关（3.5；1.1 - 11.0），并且与拥挤程度和低社会经济地位指标存在临界关联。