前列腺癌男性中人类疱疹病毒8型血清阳性率升高。

Elevated seroprevalence of human herpesvirus 8 among men with prostate cancer.

作者信息

Hoffman Linda J, Bunker Clareann H, Pellett Philip E, Trump Donald L, Patrick Alan L, Dollard Sheila C, Keenan Hillary A, Jenkins Frank J

机构信息

Department of Infectious Diseases and Microbiology, School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

出版信息

J Infect Dis. 2004 Jan 1;189(1):15-20. doi: 10.1086/380568. Epub 2003 Dec 31.

DOI:10.1086/380568

PMID:14702148

Abstract

Background. To investigate any epidemiological association between human herpesvirus (HHV)-8 and prostate cancer, we determined the prevalence of HHV-8 seropositivity among prostate cancer case and control subjects in the United States and Trinidad and Tobago.Methods. Antibodies against HHV-8 were detected in 2 independent laboratories using either indirect immunofluorescence assay (IFA) or a combination of enzyme-linked immunosorbent assay and IFA.Results. Among 138 Tobago men with prostate cancer, HHV-8 seroprevalence was 39.9%-significantly higher than that among 140 age-matched control subjects (22.9%; P=.003; odds ratio [OR], 2.24; 95% confidence interval [CI], 1.29-3.90). Among 100 US men with prostate cancer, seroprevalence was 20%-significantly higher than that of 177 blood donors (5.1%; P=.001; OR, 4.67; 95% CI, 1.91-11.65) and higher than that of 99 men with cancer not related to HHV-8 (13%; P=.253; 95% CI, 0.77-3.54).Conclusions. HHV-8 seropositivity is elevated among men with prostate cancer compared with control subjects, which suggests that HHV-8 plays a role in the development of prostate cancer.

摘要

背景。为了研究人类疱疹病毒（HHV）-8与前列腺癌之间的任何流行病学关联，我们在美国和特立尼达和多巴哥确定了前列腺癌病例组和对照组中HHV-8血清阳性的患病率。

方法。在2个独立实验室中，使用间接免疫荧光法（IFA）或酶联免疫吸附测定法与IFA相结合的方法检测抗HHV-8抗体。

结果。在138名多巴哥前列腺癌男性中，HHV-8血清阳性率为39.9%，显著高于140名年龄匹配的对照对象（22.9%；P = 0.003；优势比[OR]，2.24；95%置信区间[CI]，1.29 - 3.90）。在100名美国前列腺癌男性中，血清阳性率为20%，显著高于177名献血者（5.1%；P = 0.001；OR，4.67；95% CI，1.91 - 11.65），且高于99名与HHV-8无关的癌症男性（13%；P = 0.253；95% CI，0.77 - 3.54）。

结论。与对照对象相比，前列腺癌男性中HHV-8血清阳性率升高，这表明HHV-8在前列腺癌的发生中起作用。