Amsallem F, Gauthier R, Ramonatxo M, Counil F, Voisin M, Denjean A, Matecki S
Service central de Physiologie clinique, Unité respiratoire, Hôpital Arnaud de Villeneuve, Montpellier Cedex 5, France.
Rev Mal Respir. 2008 Apr;25(4):405-32. doi: 10.1016/s0761-8425(08)71583-3.
The present document is being produced on behalf of the French Society of the Physiology Task Force on standards for Infant Respiratory Function Testing whose aim is to provide guidelines for good laboratory practices according to the latest international recommendations. Application of such recommendations could be of particular value when attempting to develop standardized protocols in the scope of multi-centre trials. The first part resume these recommendations about apparatus, acquisition system and software for Infant Respiratory Function Testing. The second part focuses on physiological principles and practical considerations: calibration procedure, infant conditioning, tidal breathing measurements, and occlusion techniques for assessing passive respiratory mechanics, plethysmographic measurements of lung volume and airway resistance and forced expiratory flows measurements. The major problem when collecting lung function data is that of predicted values. Valid reference data, set up according to these recommendations, are, to date, still to be established. The last part of the document provides a review of the literature concerning infant respiratory function reference data and a resume of the most used of them. This document will clearly need to be updated regularly in response to advances in knowledge in this field.
本文件由法国生理学会婴儿呼吸功能测试标准特别工作组编制，其目的是根据最新国际建议提供良好实验室操作指南。在多中心试验范围内尝试制定标准化方案时，应用这些建议可能具有特别价值。第一部分总结了关于婴儿呼吸功能测试的仪器、采集系统和软件的这些建议。第二部分侧重于生理原理和实际考虑因素：校准程序、婴儿状态调整、潮气呼吸测量以及用于评估被动呼吸力学的阻断技术、肺容积和气道阻力的体积描记测量以及用力呼气流量测量。收集肺功能数据时的主要问题是预测值问题。根据这些建议建立的有效参考数据目前仍有待确定。文件的最后一部分对有关婴儿呼吸功能参考数据的文献进行了综述，并总结了其中最常用的数据。鉴于该领域知识的进展，本文件显然需要定期更新。
