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英夫利昔单抗治疗难治性川崎综合征。

Infliximab treatment in refractory Kawasaki syndrome.

作者信息

Girish Meenakshi, Subramaniam Girish

机构信息

Children's Hospital, Midas Heights, Nagpur, India.

出版信息

Indian J Pediatr. 2008 May;75(5):521-2. doi: 10.1007/s12098-008-0084-8. Epub 2008 Jun 8.

DOI:10.1007/s12098-008-0084-8
PMID:18537019
Abstract

Kawasaki syndrome is one of the commonest vasculitides in pediatric age group with devastating consequences if not treated early. Intravenous Gammaglobulin leads to rapid amelioration of clinical symptoms and significantly decreases the risk of development of coronary artery aneurysms. Occasionally, Kawasaki disease may be resistant to I/V IgG. We present our experience with one such patient who ultimately respondend to infliximab therapy.

摘要

川崎病是儿童期最常见的血管炎之一,如果不及早治疗会产生严重后果。静脉注射丙种球蛋白可使临床症状迅速改善,并显著降低冠状动脉瘤形成的风险。偶尔,川崎病可能对静脉注射免疫球蛋白耐药。我们介绍了我们对一名此类患者的治疗经验,该患者最终对英夫利昔单抗治疗有反应。

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Infliximab treatment in refractory Kawasaki syndrome.英夫利昔单抗治疗难治性川崎综合征。
Indian J Pediatr. 2008 May;75(5):521-2. doi: 10.1007/s12098-008-0084-8. Epub 2008 Jun 8.
2
[Refractory Kawasaki disease with coronary aneurysms treated with infliximab].[英夫利昔单抗治疗伴有冠状动脉瘤的难治性川崎病]
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Efficacy of infliximab in long-lasting refractory Kawasaki disease.英夫利昔单抗治疗持续性难治性川崎病的疗效
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4
Infliximab treatment for pediatric refractory Kawasaki disease.英夫利昔单抗治疗儿童难治性川崎病。
Pediatr Cardiol. 2011 Oct;32(7):1023-7. doi: 10.1007/s00246-011-0045-2. Epub 2011 Jul 20.
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Infliximab for Kawasaki syndrome.英夫利昔单抗用于川崎病
J Pediatr. 2006 Sep;149(3):426; author reply 426. doi: 10.1016/j.jpeds.2005.07.039.
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Incomplete and atypical Kawasaki disease in a young infant: severe, recalcitrant disease responsive to infliximab.一名幼儿的不完全性和非典型川崎病:对英夫利昔单抗有反应的严重、难治性疾病。
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Lancet. 2014 May 17;383(9930):1731-8. doi: 10.1016/S0140-6736(13)62298-9. Epub 2014 Feb 24.
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Infliximab for intravenous immunoglobulin resistance in Kawasaki disease: a retrospective study.英夫利昔单抗治疗川崎病静脉注射免疫球蛋白耐药:一项回顾性研究。
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Infliximab treatment of intravenous immunoglobulin-resistant Kawasaki disease.英夫利昔单抗治疗对静脉注射免疫球蛋白耐药的川崎病
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Kawasaki disease: guidelines of Italian Society of Pediatrics, part II - treatment of resistant forms and cardiovascular complications, follow-up, lifestyle and prevention of cardiovascular risks.川崎病:意大利儿科学会指南,第二部分——抵抗形式和心血管并发症的治疗、随访、生活方式和心血管风险预防。
Ital J Pediatr. 2018 Aug 30;44(1):103. doi: 10.1186/s13052-018-0529-2.
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Cordycepin inhibits lipopolysaccharide (LPS)-induced tumor necrosis factor (TNF)-α production via activating amp-activated protein kinase (AMPK) signaling.虫草素通过激活腺苷酸活化蛋白激酶(AMPK)信号通路抑制脂多糖(LPS)诱导的肿瘤坏死因子(TNF)-α生成。
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本文引用的文献

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Randomized trial of pulsed corticosteroid therapy for primary treatment of Kawasaki disease.脉冲式皮质类固醇疗法用于川崎病初始治疗的随机试验。
N Engl J Med. 2007 Feb 15;356(7):663-75. doi: 10.1056/NEJMoa061235.
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Kawasaki disease: are we missing the diagnosis?川崎病:我们是否漏诊了?
Indian J Pediatr. 2005 Oct;72(10):873-5. doi: 10.1007/BF02731119.
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Current perspectives on Kawasaki disease.川崎病的当前观点
Childhood cutaneous vasculitis: a comprehensive appraisal.
儿童皮肤血管炎:全面评估
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Infliximab for the treatment of intravenous immunoglobulin resistant Kawasaki disease complicated by coronary artery aneurysms: a case report.英夫利昔单抗治疗静脉注射免疫球蛋白耐药性川崎病并发冠状动脉瘤:一例报告。
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Infliximab treatment for refractory Kawasaki syndrome.英夫利昔单抗治疗难治性川崎综合征。
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Evidence for RANTES, monocyte chemotactic protein-1, and macrophage inflammatory protein-1 beta expression in Kawasaki disease.RANTES、单核细胞趋化蛋白-1及巨噬细胞炎性蛋白-1β在川崎病中表达的证据
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