Yanagawa H, Yashiro M, Nakamura Y, Kawasaki T, Kato H
Department of Public Health, Jichi Medical School, Tochigi-ken, Japan.
Arch Pediatr Adolesc Med. 1995 Jul;149(7):779-83. doi: 10.1001/archpedi.1995.02170200069011.
To describe the long-term trend of incidence and other epidemiological pictures of Kawasaki disease in Japan, by using the results of 12 nationwide epidemiological surveys on Kawasaki disease that have been conducted throughout Japan (ie, surveys that have encompassed the pediatric departments of hospitals with more than 100 beds) every 2 years since 1970.
At the end of December 1992, the total number of patients with this disease was 116,848 (males, 67,815; females, 49,033; male-female ratio, 1.38). The number of cases increased year by year, with three outbreaks in 1979, 1982, and 1986. There have been no cyclical changes since 1986. The incidence was higher in males and in those children who were 1 year of age or younger. The fatality rate decreased from 1% in 1974 to 0.04% in 1992.
The patterns of descriptive epidemiology, such as seasonality and cyclical changes in incidence, supported the theory of an infectious agent as the causal agent. However, the incidence data since 1986 provide less support for an infectious theory.
利用自1970年起在日本全国每两年开展一次的12次川崎病全国性流行病学调查（即涵盖拥有100张以上床位医院儿科的调查）结果，描述日本川崎病发病率的长期趋势及其他流行病学特征。
1992年12月底，该病患者总数为116,848例（男性67,815例，女性49,033例，男女比例为1.38）。病例数逐年增加，在1979年、1982年和1986年出现三次发病高峰。1986年以来未出现周期性变化。男性及1岁及以下儿童发病率较高。病死率从1974年的1%降至1992年的0.04%。
描述性流行病学特征，如发病率的季节性和周期性变化，支持感染因子作为病因的理论。然而，1986年以来的发病率数据对感染理论的支持较少。
