Burdon Kathryn P, Lehtinen Allison B, Langefeld Carl D, Carr J Jeffrey, Rich Stephen S, Freedman Barry I, Herrington David, Bowden Donald W
Department of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.
Diab Vasc Dis Res. 2008 Jun;5(2):128-34. doi: 10.3132/dvdr.2008.021.
Epoxide hydrolase is involved in metabolism of vasoactive and anti-inflammatory epoxyeicosatrienoic acids to their corresponding diols. Consequently, epoxide hydrolase 2 (EPHX2) is a candidate cardiovascular disease (CVD) gene. We investigated EPHX2 for association with subclinical CVD in European American (EA) and African American (AA) families from the Diabetes Heart Study. The R287Q polymorphism was associated with carotid artery calcified plaque (CarCP) in EAs. Other EPHX2 polymorphisms were associated with coronary artery calcified plaque (CorCP), CarCP or carotid artery intima-media thickness (IMT). Polymorphism rs7837347 was associated with all traits in the AAs (p=0.003, 0.001 and 0.017, respectively). Polymorphism rs7003694 displayed association with IMT (p=0.017) and, along with rs747276, a trend towards association with CorCP in diabetic EAs (p=0.057 and 0.080, respectively). These results provide additional evidence that EPHX2 contributes to the risk of subclinical CVD, although the true trait defining polymorphisms may not be identified and the effect size could be small.
环氧水解酶参与将血管活性和抗炎性环氧二十碳三烯酸代谢为其相应的二醇。因此，环氧水解酶2（EPHX2）是心血管疾病（CVD）的候选基因。我们在糖尿病心脏研究中的欧美（EA）和非裔美国（AA）家庭中研究了EPHX2与亚临床CVD的关联。R287Q多态性与EA人群的颈动脉钙化斑块（CarCP）相关。其他EPHX2多态性与冠状动脉钙化斑块（CorCP）、CarCP或颈动脉内膜中层厚度（IMT）相关。多态性rs7837347与AA人群的所有性状相关（p值分别为0.003、0.001和0.017）。多态性rs7003694与IMT相关（p=0.017），并且在糖尿病EA人群中，与rs747276一起显示出与CorCP相关的趋势（p值分别为0.057和0.080）。这些结果提供了额外的证据，表明EPHX2会增加亚临床CVD的风险，尽管可能无法确定真正定义性状的多态性，且效应大小可能较小。
