树枝状大分子与DNA：纳米材料和生物学中两种特殊拓扑结构的组合

Dendrimers and DNA: combinations of two special topologies for nanomaterials and biology.

作者信息

Caminade Anne-Marie, Turrin Cédric-Olivier, Majoral Jean-Pierre

机构信息

Laboratoire de Chimie de Coordination du CNRS, 205 route de Narbonne, Toulouse Cedex 4, France.

出版信息

Chemistry. 2008;14(25):7422-32. doi: 10.1002/chem.200800584.

DOI:10.1002/chem.200800584

PMID:18537210

Abstract

Interactions between two precisely defined three-dimensional architectures (DNA and dendrimers) are described. Highly synergetic effects occur, as illustrated in two cases: dendrimers can be used as three-dimensional linkers for oligonucleotides, affording highly sensitive microarrays (biochips), and positively charged dendrimers strongly interact with DNA, allowing penetration inside cells (genetic transfection).

摘要

本文描述了两种精确界定的三维结构（DNA和树枝状聚合物）之间的相互作用。研究发现，二者之间存在高度协同效应，具体体现在两个方面：树枝状聚合物可作为寡核苷酸的三维连接体，用于制备高灵敏度微阵列（生物芯片）；带正电荷的树枝状聚合物能与DNA发生强烈相互作用，实现细胞内递送（基因转染）。