Tondreau Aaron M, Lobkovsky Emil, Chirik Paul J
Department of Chemistry and Chemical Biology, Baker Laboratory, Cornell University, Ithaca, New York 14853, USA.
Org Lett. 2008 Jul 3;10(13):2789-92. doi: 10.1021/ol800906b. Epub 2008 Jun 7.
Bis(imino)pyridine iron dinitrogen and dialkyl complexes are well-defined precatalysts for the chemo- and regioselective reduction of aldehydes and ketones. Efficient carbonyl hydrosilylation is observed at low (0.1-1.0 mol %) catalyst loadings and with 2 equiv of either PhSiH(3) or Ph(2)SiH(2), representing one of the most active iron-catalyzed carbonyl reductions reported to date.
双（亚氨基）吡啶二氮和二烷基铁配合物是用于醛和酮的化学选择性和区域选择性还原的明确预催化剂。在低（0.1 - 1.0 mol%）催化剂负载量下，使用2当量的PhSiH₃或Ph₂SiH₂时，可观察到高效的羰基硅氢化反应，这是迄今为止报道的最具活性的铁催化羰基还原反应之一。
