Vercellino Marco, Votta Barbara, Condello Cecilia, Piacentino Chiara, Romagnolo Alberto, Merola Aristide, Capello Elisabetta, Mancardi Giovanni Luigi, Mutani Roberto, Giordana Maria Teresa, Cavalla Paola
Department of Neuroscience, University of Turin, Italy.
J Neuroimmunol. 2008 Aug 13;199(1-2):133-41. doi: 10.1016/j.jneuroim.2008.04.035. Epub 2008 Jun 9.
An immunological function has been proposed for the choroid plexus (CP). In multiple sclerosis (MS) brains, CPs show (immunohistochemistry to HLA-DR, CD3, CD20, CD68, VCAM-1, CD138) T lymphocytes in vessels and stroma, VCAM-1 expression on endothelia, intense HLA-DR immunostaining on cells in CP stroma, among CP epithelium and on epiplexus cells. CPs in control or amyotrophic lateral sclerosis brains do not show such inflammatory changes. Intense CP inflammation is observed in viral encephalitis. Changes in MS CPs suggest persisting immune activation, with intensity similar to acute encephalitis, even in MS phases in which neurodegeneration prevails. In MS, CPs could represent a site for lymphocyte entry in the CSF and for CSF antigens presentation.
脉络丛（CP）被认为具有免疫功能。在多发性硬化症（MS）患者的大脑中，脉络丛（免疫组化检测HLA-DR、CD3、CD20、CD68、VCAM-1、CD138）显示血管和基质中有T淋巴细胞，内皮细胞上有VCAM-1表达，脉络丛基质中的细胞、脉络丛上皮细胞和丛间细胞上有强烈的HLA-DR免疫染色。对照或肌萎缩侧索硬化症患者大脑中的脉络丛未显示出此类炎症变化。在病毒性脑炎中观察到脉络丛有强烈炎症。MS患者脉络丛的变化表明免疫激活持续存在，其强度与急性脑炎相似，即使在以神经退行性变为主的MS阶段也是如此。在MS中，脉络丛可能是淋巴细胞进入脑脊液和脑脊液抗原呈递的部位。
