Carstensen H E
Scand J Thorac Cardiovasc Surg. 1975;9(3):212-9. doi: 10.3109/14017437509138642.
A simple membrane oxygenator for isolated organ perfusion is described. The membrane employed consisted of an ordinary silicone rubber tubing, 2 mm internal diameter, 0.3 mm wall thickness, the length of the tubing varying according to the required gas transfer. When describing the capacity of the oxygenator, it was found that the maximum gas transfer rate per unit membrane surface was an inadequate measure, since this would vary with both flow rate through the oxygenator and the gas binding capacity of the perfusate. The following formula for the function describing the relation between maximally possible change in gas concentration in the perfusate (C), flow rate (F) and actual change in gas concentration in the perfusate (U) was proposed: U=C-e(-bF), b being a constant specific for the gas and the membrane. This formula was tested by a series of in vitro experiments and proved to give a valid description of the capacity of the oxygenator. It was also found that carbon dioxide was always more easily transferred than oxygen, so that oxygen transfer capcity was the limiting factor in the use of the oxygenator. To facilitate the construction of the right size membrane, a nomogram was constructed for oxygen transfer.
描述了一种用于离体器官灌注的简易膜式氧合器。所使用的膜由普通硅橡胶管组成，内径2毫米，壁厚0.3毫米，管的长度根据所需的气体传输而变化。在描述氧合器的容量时，发现单位膜面积的最大气体传输速率是一个不充分的衡量标准，因为这会随通过氧合器的流速和灌注液的气体结合能力而变化。提出了以下描述灌注液中气体浓度的最大可能变化（C）、流速（F）和灌注液中气体浓度的实际变化（U）之间关系的函数公式：U = C - e^(-bF)，其中b是气体和膜的特定常数。该公式通过一系列体外实验进行了测试，证明能有效描述氧合器的容量。还发现二氧化碳总是比氧气更容易传输，因此氧气传输能力是氧合器使用中的限制因素。为便于构建合适尺寸的膜，绘制了氧气传输列线图。
