C型病毒在易患淋巴瘤性麻痹的野生小鼠中的表达。
Type C virus expression in lymphoma-paralysis-prone wild mice.
作者信息
Gardner M B, Klement V, Rongey R R, McConahey P, Estes J D, Huebner R J
出版信息
J Natl Cancer Inst. 1976 Sep;57(3):585-90. doi: 10.1093/jnci/57.3.585.
Wild mice trapped near Lake Casitas (LC) in southern California showed a high prevalence of infectious type C virus in the liver, spleen, and thymus within the first few weeks of life. By young adulthood about 80% of LC mice (including their genital tissues) were infected. Virus isolates from these mice cause lymphoma and lower limb paralysis under both natural and experimental conditions. Mice destined to develop paralysis showed higher levels of serum gs antigen early in life, whereas mice destined to develop lymphoma or remain free of these diseases could not be distinguished by this test. The individual variation in virus expression suggested that differences in virus type or in the immune or other host defense mechanisms greatly influenced susceptibility or resistance to indigenous type C virus-caused disease in LC wild mice.
在加利福尼亚州南部卡西塔斯湖（LC）附近捕获的野生小鼠在出生后的头几周内，肝脏、脾脏和胸腺中感染性C型病毒的患病率很高。到成年早期，约80%的LC小鼠（包括其生殖组织）受到感染。从这些小鼠中分离出的病毒在自然和实验条件下都会引发淋巴瘤和下肢麻痹。注定会发生麻痹的小鼠在生命早期血清gs抗原水平较高，而注定会发生淋巴瘤或未患这些疾病的小鼠无法通过该检测区分。病毒表达的个体差异表明，病毒类型或免疫或其他宿主防御机制的差异极大地影响了LC野生小鼠对本土C型病毒所致疾病的易感性或抵抗力。
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