Whipp S C
Physiopathology Research Unit, USDA, Ames, IA 50010.
Am J Vet Res. 1991 May;52(5):734-7.
The Escherichia coli heat-stable enterotoxin (STb) is the most prevalent toxin associated with diarrheagenic E coli isolates of porcine origin. Unequivocal biological activity of this toxin has been observed only in swine intestine. In this study, when endogenous protease activity was blocked with soybean trypsin inhibitor, intestinal secretion was stimulated by STb in jejunal loops of rats, mice, calves, and rabbits. Compared with pigs, rats, mice, and calves, rabbits were relatively insensitive to STb. These data demonstrate that the activity of STb is not a species-specific toxic activity; there is species variation in sensitivity to STb, and some common laboratory animals may have potential to be used to measure biological activity of STb.
大肠杆菌热稳定肠毒素（STb）是与猪源致泻性大肠杆菌分离株相关的最普遍毒素。仅在猪肠道中观察到这种毒素明确的生物活性。在本研究中，当用大豆胰蛋白酶抑制剂阻断内源性蛋白酶活性时，STb可刺激大鼠、小鼠、犊牛和家兔空肠肠袢的肠分泌。与猪、大鼠、小鼠和犊牛相比，家兔对STb相对不敏感。这些数据表明，STb的活性不是种特异性毒性活性；对STb的敏感性存在种属差异，一些常见实验动物可能有潜力用于测定STb的生物活性。
