Lee Byung Hwa, Kim Eun-Joo, Ku Bon D, Choi Kyung Mook, Seo Sang Won, Kim Gyeong-Moon, Chung Chin-Sang, Heilman Kenneth M, Na Duk L
Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Cogn Behav Neurol. 2008 Jun;21(2):73-6. doi: 10.1097/WNN.0b013e3181772101.
Little is known about cognitive differences between patients showing neglect and those without neglect in their acute stroke stage. The aim of this study was to investigate how the patients with neglect (N+) differ from those without neglect (N-) in general cognitive function assessed by the Mini-Mental State Examination (MMSE).
Patients consisted of 98 consecutive patients with acute right hemisphere stroke. The patients underwent neglect test battery followed by MMSE in the same day.
The frequency of cognitive deficits in N+ group was higher than that of N- group (74.1% vs. 35.0%). A regression analysis, after controlling for lesion volume, age, and education, showed that neglect was a significant predictor of low MMSE score. Among MMSE subdomains, the severity of neglect was related to poor performances on episodic memory (orientation and 3-word recall), working memory/calculation (serial 7s), and constructional praxis (interlocking pentagons).
These results suggest that hemispatial neglect is associated with several forms of cognitive deficits in patients with acute right hemisphere stroke.
对于急性卒中阶段出现偏侧空间忽视的患者与未出现偏侧空间忽视的患者之间的认知差异，人们了解甚少。本研究的目的是调查通过简易精神状态检查表（MMSE）评估的一般认知功能方面，有偏侧空间忽视的患者（N+）与无偏侧空间忽视的患者（N-）有何不同。
研究对象为98例连续的急性右半球卒中患者。患者在同一天接受偏侧空间忽视测试组，随后进行MMSE测试。
N+组认知缺陷的发生率高于N-组（74.1%对35.0%）。在控制了病变体积、年龄和教育程度后进行的回归分析表明，偏侧空间忽视是MMSE低分的一个显著预测因素。在MMSE子领域中，偏侧空间忽视的严重程度与情景记忆（定向和3词回忆）、工作记忆/计算（连续减7）和结构性实践（连锁五边形）方面的表现不佳有关。
这些结果表明，半侧空间忽视与急性右半球卒中患者的几种认知缺陷形式有关。
