Nedeljković M, Matović V
Department of Toxicological Chemistry, School of Pharmacy, University of Belgrade, Yugoslavia.
Arh Hig Rada Toksikol. 1991 Mar;42(1):43-6.
Placental transfer of fluoride was investigated by fluoride determination in the bones and teeth of newborn rabbits whose mothers had been treated with fluoride during pregnancy. The mothers were given doses of 0, 0.10, 0.52 and 1.05 mmol fluoride per kg body weight as sodium fluoride, from the 16th day after conception to the end of pregnancy. All the doses produced a significant increase of fluoride level in the bones and teeth of newborn rabbits, indicating that the placenta was no barrier for the passage of fluoride.
通过对孕期接受氟化物治疗的母兔所产新生兔骨骼和牙齿中的氟化物进行测定，研究了氟化物的胎盘转运情况。从受孕第16天到妊娠结束，母兔按每千克体重0、0.10、0.52和1.05毫摩尔氟化物的剂量给予氟化钠。所有剂量均使新生兔骨骼和牙齿中的氟化物水平显著升高，表明胎盘对氟化物的通过没有屏障作用。
