Seidell J C, Cigolini M, Charzewska J, Ellsinger B M, Björntorp P, Hautvast J G, Szostak W
Department of Human Nutrition, Agricultural University, Wageningen, The Netherlands.
Atherosclerosis. 1991 Apr;87(2-3):203-10. doi: 10.1016/0021-9150(91)90022-u.
We studied male/female differences in serum lipids in randomly selected 38-year-old men (n = 337) and women (n = 342) from various cities in The Netherlands, Sweden, Italy, and Poland. Overall, men had higher triglycerides and total cholesterol levels and lower HDL-levels compared to women (P less than 0.001). Adjustment for smoking habits, city, and body mass index did not remove the gender difference. Further adjustments for waist circumference alone and waist/hip and waist/thigh circumference ratio removed the gender differences in serum triglycerides and total cholesterol. Only adjustment for waist/thigh ratio removed the gender difference in HDL-cholesterol but linear relationships were different in men and women. The average male/female difference in serum lipids, particularly for total and LDL-cholesterol varied considerably among centers. In analyses of the data from the separate centers we found that sex differences in serum triglycerides and HDL-cholesterol in all 4 centers disappeared when adjusted for waist circumference alone and for waist/hip and waist/thigh ratio. For total and LDL-cholesterol, however, adjustment for circumference ratios tended to increase the male/female difference in 2 of the 4 centers. It is concluded that, in European men and women, fat distribution may be responsible for male/female differences in serum triglycerides but that such conclusions are less clear for HDL-, total- and LDL-cholesterol.
我们对来自荷兰、瑞典、意大利和波兰不同城市的随机选取的38岁男性（n = 337）和女性（n = 342）的血脂进行了男女差异研究。总体而言，与女性相比，男性的甘油三酯和总胆固醇水平更高，高密度脂蛋白（HDL）水平更低（P < 0.001）。对吸烟习惯、城市和体重指数进行调整后，性别差异依然存在。仅对腰围以及腰臀比和腰大腿围比进行进一步调整后，血清甘油三酯和总胆固醇的性别差异消失。仅对腰大腿围比进行调整消除了HDL胆固醇的性别差异，但男女的线性关系有所不同。各中心之间血清脂质的平均男女差异，尤其是总胆固醇和低密度脂蛋白（LDL）胆固醇的差异相当大。在对各独立中心的数据进行分析时，我们发现，在所有4个中心，仅对腰围以及腰臀比和腰大腿围比进行调整后，血清甘油三酯和HDL胆固醇的性别差异消失。然而，对于总胆固醇和LDL胆固醇，在4个中心中的2个中心，对围度比进行调整往往会加大男女差异。得出的结论是，在欧洲男性和女性中，脂肪分布可能是血清甘油三酯男女差异的原因，但对于HDL胆固醇、总胆固醇和LDL胆固醇，这样的结论不太明确。
