Seidell J C, Cigolini M, Charzewska J, Ellsinger B M, Di Biase G, Björntorp P, Hautvast J G, Contaldo F, Szostak V, Scuro L A
Department of Human Nutrition, Agricultural University, Wageningen, The Netherlands.
J Clin Epidemiol. 1990;43(1):21-34. doi: 10.1016/0895-4356(90)90052-q.
We studied fat distribution and metabolic risk factors in 434 38-year old women selected from population registrars in 5 cities in different parts of Europe. In the present study we focussed on the geographical variation in serum concentrations of free testosterone and its relation to measures of obesity, fat distribution and indicators of cardiovascular risk (serum lipids, insulin, and blood pressure). There were significant differences in free testosterone levels (F = 5.4, p less than 0.001) with lowest levels in Polish women (mean +/- SEM: 1.56 +/- 0.08 pg/ml) and highest in women from Italy (2.07 +/- 0.12 pg/ml). In the pooled data, free testosterone levels were correlated with several anthropometric variables (strongest with subscapular/triceps ratio r = 0.27, with subscapular skinfold and waist/thigh circumference ratio r = 0.25 p-values less than 0.001). In addition, free testosterone was positively correlated with serum total cholesterol (r = 0.11), HDL/total cholesterol fraction (r = 0.12), serum insulin (r = 0.20) and diastolic blood pressure (r = 0.15). These associations remained significant after adjustment for body mass index and waist/thigh ratio (not for diastolic blood pressure) but were no longer significant after further adjustment for insulin levels. There were considerable differences in strength of the associations mentioned between the 5 centers. We conclude that degree of obesity, fat distribution and serum levels of free testosterone all, to a limited degree, contribute to the metabolic profile of randomly selected 38-year old women but that adjustment for such variables increases the differences in metabolic profiles between women from different centers of Europe.
我们对从欧洲不同地区5个城市的人口登记处选取的434名38岁女性的脂肪分布和代谢风险因素进行了研究。在本研究中，我们重点关注游离睾酮血清浓度的地理差异及其与肥胖测量指标、脂肪分布和心血管风险指标（血脂、胰岛素和血压）之间的关系。游离睾酮水平存在显著差异（F = 5.4，p < 0.001），波兰女性的水平最低（均值±标准误：1.56 ± 0.08 pg/ml），意大利女性的水平最高（2.07 ± 0.12 pg/ml）。在汇总数据中，游离睾酮水平与多个身体测量变量相关（与肩胛下/三头肌比值相关性最强，r = 0.27，与肩胛下皮褶厚度和腰/大腿围比值相关性为r = 0.25，p值均小于0.001）。此外，游离睾酮与血清总胆固醇（r = 0.11）、高密度脂蛋白/总胆固醇比例（r = 0.12）、血清胰岛素（r = 0.20）和舒张压（r = 0.15）呈正相关。在调整体重指数和腰/大腿比值后（舒张压除外），这些关联仍然显著，但在进一步调整胰岛素水平后不再显著。5个中心之间上述关联的强度存在相当大的差异。我们得出结论，肥胖程度、脂肪分布和游离睾酮血清水平在一定程度上都对随机选取的38岁女性的代谢特征有影响，但对这些变量进行调整会增加欧洲不同中心女性代谢特征的差异。
