Ehehalt S, Blumenstock G, Willasch A M, Hub R, Ranke M B, Neu A
University Children's Hospital, Eberhard-Karls-University, Tübingen, Germany.
Diabet Med. 2008 Jun;25(6):755-7. doi: 10.1111/j.1464-5491.2008.02450.x.
To assess the incidence and the trend in incidence of Type 1 diabetes (T1DM) in children and adolescents < 15 years of age in Baden-Württemberg (BW), Germany.
BW is Germany's third largest federal state. All 31 paediatric departments in BW and one diabetes centre participated in the study. Case registration was done according to the EURODIAB criteria. The degree of ascertainment was 97.2%.
From 1987 to 2003, the age- and sex-standardized incidence rate was 14.1/100,000 per year [95% confidence interval (CI) 13.7, 14.6, n = 4017]. The estimated annual increase in incidence was 3.8% (95% CI 1.1, 6.6). Compared with the first years of our registry, the current mean number of new cases of T1DM has doubled (1987-1989, n = 153; 2000-2003, n = 302). Generally, the highest rise in incidence occurred in the youngest age group of 0-4-year-old patients (5.8%; 95% CI 2.5, 9.3), followed by the age groups 5-9 (3.4%; 95% CI 0.8, 6.0) and 10-14 (2.7%; 95% CI 0.3, 5.1).
In Germany, the number of children and adolescents with new-onset T1DM has been rising at a faster pace than expected. A distinct shift to younger age at onset has been observed in Germany.
评估德国巴登 - 符腾堡州（BW）15岁以下儿童和青少年1型糖尿病（T1DM）的发病率及发病率趋势。
BW是德国第三大联邦州。BW的所有31个儿科部门和一个糖尿病中心参与了该研究。病例登记按照欧洲糖尿病研究组（EURODIAB）标准进行。确诊率为97.2%。
1987年至2003年，年龄和性别标准化发病率为每年14.1/10万[95%置信区间（CI）13.7, 14.6，n = 4017]。发病率的估计年增长率为3.8%（95%CI 1.1, 6.6）。与我们登记的最初几年相比，目前T1DM新发病例的平均数量增加了一倍（1987 - 1989年，n = 153；2000 - 2003年，n = 302）。一般来说，发病率上升最高的是0 - 4岁的最年幼患者组（5.8%；95%CI 2.5, 9.3），其次是5 - 9岁组（3.4%；95%CI 0.8, 6.0）和10 - 14岁组（2.7%；95%CI 0.3, 5.1）。
在德国，新诊断为T1DM的儿童和青少年数量增长速度超过预期。在德国已观察到发病年龄明显向低龄化转变。
