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开放性支架移植物技术治疗广泛性主动脉弓疾病的长期疗效

Long-term results of the open stent-grafting technique for extended aortic arch disease.

作者信息

Shimamura Kazuo, Kuratani Toru, Matsumiya Goro, Kato Masaaki, Shirakawa Yukitoshi, Takano Hiroshi, Ohta Noriyuki, Sawa Yoshiki

机构信息

Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, Osaka, Japan.

出版信息

J Thorac Cardiovasc Surg. 2008 Jun;135(6):1261-9. doi: 10.1016/j.jtcvs.2007.10.056.

Abstract

OBJECTIVE

This report elucidates the long-term safety and effectiveness of extended aortic arch replacement with an open stent-grafting technique from our 12 years of experience.

METHODS

From 1994 to 2004, 126 patients (mean age 67.8 years) with different pathologic conditions of the aortic arch with extension to the descending aorta (57 dissections [acute/chronic = 31/26] and 69 aneurysms) were operated on with an open stent-grafting technique. During deep hypothermic circulatory arrest with selective cerebral perfusion, the stent graft was delivered through the transected proximal aortic arch, and arch replacement with a 4-branched prosthesis was performed.

RESULTS

Operative mortality within 30 days was 3.2%. Perioperative morbidity included 7 (5.6%) strokes and 8 (6.3%) spinal injuries (paraplegia in 3, transient paraparesis in 5). Sixty-three percent of the patients were extubated within 24 hours. In long-term follow-up (mean 60.4 +/- 36.5 months, maximum 153 months), survival was 81.1%, 63.3%, and 53.7% at 1, 5, and 8 years. Five (3.9%) late endoleaks were observed but treated with successful additional endovascular repair. Freedom from endoleaks was 98.0%, 91.1%, and 91.1% for 1, 5, and 8 years, respectively.

CONCLUSION

Long-term observation showed safety and good durability of the open stent-grafting technique for aortic arch disease. This technique could be an attractive treatment option for aortic arch aneurysm with distal extension and aortic dissection requiring aortic arch replacement.

摘要

目的

本报告根据我们12年的经验阐明采用开放支架型人工血管技术进行主动脉弓延长置换术的长期安全性和有效性。

方法

1994年至2004年,126例主动脉弓合并降主动脉不同病理状况的患者(平均年龄67.8岁)(57例夹层动脉瘤[急性/慢性=31/26]和69例动脉瘤)接受了开放支架型人工血管技术手术。在选择性脑灌注的深低温循环停搏期间,将支架型人工血管经横断的主动脉弓近端置入,并使用四分支人工血管进行主动脉弓置换。

结果

30天内手术死亡率为3.2%。围手术期并发症包括7例(5.6%)中风和8例(6.3%)脊髓损伤(3例截瘫,5例短暂性下肢轻瘫)。63%的患者在24小时内拔管。在长期随访中(平均60.4±36.5个月,最长153个月),1年、5年和8年的生存率分别为81.1%、63.3%和53.7%。观察到5例(3.9%)晚期内漏,但通过额外的成功血管腔内修复进行了治疗。1年、5年和8年无内漏的比例分别为98.0%、91.1%和91.1%。

结论

长期观察表明,开放支架型人工血管技术治疗主动脉弓疾病具有安全性和良好的耐久性。对于合并远端延伸的主动脉弓动脉瘤和需要进行主动脉弓置换的主动脉夹层,该技术可能是一种有吸引力的治疗选择。

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