Platelet tissue factor: how did it get there and is it important?

Recently, the presence of functionally active tissue factor (TF) in platelets has been reported by several groups. In this location, TF is postulated to play an important role in the propagation phase of thrombus formation. Although the existence of platelet TF still remains controversial to some extent, a review of the current literature proposes at least three distinct sources of "platelet-associated TF" in those laboratories that have reported its presence: (1) TF that is taken up in the form of circulating microparticles, usually derived from monocytes; (2) TF stored in the alpha-granules of platelets that may have been taken up and/or endogenously synthesized; and (3) TF that is synthesized and expressed on the plasma membrane of mature platelets. These pathways are not mutually exclusive, and the dominant mechanism may depend on the state of platelet activation and, possibly, on other host factors that differ in physiological hemostasis versus pathological thrombosis. This brief review will summarize the state-of-the-art understanding on the origins and possible role of platelet TF.