Department of Blood Transfusion, The Affiliated Hospital of Qingdao University, Qingdao, China.
Front Immunol. 2023 Apr 17;14:1165989. doi: 10.3389/fimmu.2023.1165989. eCollection 2023.
It has been confirmed that platelets play a key role in tumorigenesis. Tumor-activated platelets can recruit blood cells and immune cells to migrate, establish an inflammatory tumor microenvironment at the sites of primary and metastatic tumors. On the other hand, they can also promote the differentiation of mesenchymal cells, which can accelerate the proliferation, genesis and migration of blood vessels. The role of platelets in tumors has been well studied. However, a growing number of studies suggest that interactions between platelets and immune cells (e.g., dendritic cells, natural killer cells, monocytes, and red blood cells) also play an important role in tumorigenesis and tumor development. In this review, we summarize the major cells that are closely associated with platelets and discuss the essential role of the interaction between platelets with these cells in tumorigenesis and tumor development.
已经证实，血小板在肿瘤发生中起着关键作用。肿瘤激活的血小板可以募集血细胞和免疫细胞迁移，在原发性和转移性肿瘤部位建立炎症性肿瘤微环境。另一方面，它们还可以促进间充质细胞的分化，从而加速血管的增殖、生成和迁移。血小板在肿瘤中的作用已经得到了很好的研究。然而，越来越多的研究表明，血小板与免疫细胞（如树突状细胞、自然杀伤细胞、单核细胞和红细胞）之间的相互作用也在肿瘤发生和肿瘤发展中起着重要作用。在这篇综述中，我们总结了与血小板密切相关的主要细胞，并讨论了血小板与这些细胞相互作用在肿瘤发生和肿瘤发展中的重要作用。
