Parnaik Veena K
Center for Cellular and Molecular Biology, Hyderabad, India.
Int Rev Cell Mol Biol. 2008;266:157-206. doi: 10.1016/S1937-6448(07)66004-3.
Lamins are the major architectural proteins of the nucleus and are essential for nuclear integrity and assembly. Lamins are also involved in the organization of nuclear functions such as DNA replication, transcription, and repair. Mutations in the human lamin genes lead to highly debilitating genetic diseases that affect a number of different tissues such as muscle, adipose, and neuronal tissues, or cause premature aging syndromes. The observed interactions of lamins with inner nuclear membrane proteins, chromatin, and various regulatory factors have given important insights into the role of lamins in cellular processes and tissue-specific signaling pathways.
核纤层蛋白是细胞核的主要结构蛋白，对于细胞核的完整性和组装至关重要。核纤层蛋白还参与DNA复制、转录和修复等核功能的组织。人类核纤层蛋白基因的突变会导致严重的遗传性疾病，这些疾病会影响多种不同组织，如肌肉、脂肪和神经组织，或导致早衰综合征。观察到的核纤层蛋白与内核膜蛋白、染色质和各种调节因子的相互作用，为核纤层蛋白在细胞过程和组织特异性信号通路中的作用提供了重要见解。
