Ish-Shalom Sophia, Segal Elena, Salganik Tina, Raz Batia, Bromberg Irvin L, Vieth Reinhold
Metabolic Bone Diseases Unit, Rambam Health Care Campus, Haifa, Israel.
J Clin Endocrinol Metab. 2008 Sep;93(9):3430-5. doi: 10.1210/jc.2008-0241. Epub 2008 Jun 10.
Different dosing protocols have been used for vitamin D supplementation, but there has been a lack of comparative data among them.
Our objective was to determine whether the same cumulative dose of vitamin D3 produces different effects if it is given daily, weekly, or monthly.
Women, age 81 +/- 8 yr (+/- sd, n = 48), who had undergone surgery to repair hip fracture were randomized to vitamin D3-supplementation protocols at 1,500 IU daily, or 10,500 IU once weekly, or 45,000 IU once every 28 d. The primary outcome measure was the serum 25-hydroxyvitamin D [25(OH)D] concentration attained.
Initially, serum 25(OH)D concentrations for daily, weekly, and monthly groups were, respectively, 15.13 +/- 6.9, 15.7 +/- 10.1, and 16.2 +/- 10.1 ng/ml. By d 7, these had increased significantly in all the groups (P < 0.001). On the first day after the monthly dose, both serum 25(OH)D and serum 1,25-dihydroxyvitamin D had increased significantly (P < 0.012 each), whereas these did not change significantly on the day after daily or weekly doses. After 2 months, serum 25(OH)D with daily, weekly, and monthly dosing were, respectively, 33.2 +/- 8.5, 29.2 +/- 8.9, and 37.1 +/- 10.3 ng/ml; there were no significant differences among these values.
Supplementation with vitamin D can be achieved equally well with daily, weekly, or monthly dosing frequencies. Therefore, the choice of dose frequency can be based on whichever approach will optimize an individual's adherence with long-term vitamin D supplementation.
维生素D补充剂采用了不同的给药方案，但缺乏这些方案之间的比较数据。
我们的目的是确定相同累积剂量的维生素D3每日、每周或每月给药是否会产生不同效果。
81±8岁（±标准差，n = 48）接受过髋部骨折修复手术的女性被随机分为维生素D3补充方案组，分别为每日1500 IU，或每周10500 IU，或每28天45000 IU。主要结局指标是达到的血清25-羟基维生素D [25(OH)D]浓度。
最初，每日、每周和每月组的血清25(OH)D浓度分别为15.13±6.9、15.7±10.1和16.2±10.1 ng/ml。到第7天，所有组的这些浓度均显著升高（P < 0.001）。在每月剂量后的第一天，血清25(OH)D和血清1,25-二羟基维生素D均显著升高（各P < 0.012），而在每日或每周剂量后的当天这些指标无显著变化。2个月后，每日、每周和每月给药的血清25(OH)D分别为33.2±8.5、29.2±8.9和37.1±10.3 ng/ml；这些值之间无显著差异。
每日、每周或每月的给药频率补充维生素D的效果相同。因此，剂量频率的选择可以基于能优化个体长期维生素D补充依从性的任何一种方法。
