Fu Kun, Meng Zhi-bin, Li Jun, Li Hong-chao
Department of Orthopaedics, Affiliated Hospital of Hainan Medical College, Haikou, China.
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2008 May;33(5):421-4.
To observe the clinical effect of repairing bone defectin post-operation benign tumor with coralline hydroxyapatite(CHAP).
The natural coralline was treated into coralline hydroxyapatite by "hydrothermal exchanging" at specific condition. The CHAP was implanted into the lesion after bone tumor curettage to 25 patients. The sizes of bone defect ranged from 0.8 cm x 0.5 cm x 0.5 cm to 10 cm x 3.5 cm x 2 cm.
All patients had no abnormal local or systemic reactions. X-ray showed that there was osteogenesis at the cortical bone 1 month post-operation. The density of CHAP gradually reduced from 3 months. The clinical healing time was 4 months. The CHAP was nearly completely absorbed 18 months post-operation.
The CHAP has favourable histocompatibility and osteroconduction in vivo. There is corresponding synchronization between bone formation with CHAP biodegradation. The CHAP is an excellent bone defect repairing material.
观察珊瑚羟基磷灰石（CHAP）修复术后良性骨肿瘤骨缺损的临床效果。
将天然珊瑚经特定条件下的“水热交换”处理制成珊瑚羟基磷灰石。将CHAP植入25例骨肿瘤刮除术后的骨缺损处，骨缺损大小为0.8 cm×0.5 cm×0.5 cm至10 cm×3.5 cm×2 cm。
所有患者局部及全身均无异常反应。X线显示术后1个月皮质骨有骨生成。CHAP密度从3个月起逐渐降低。临床愈合时间为4个月。术后18个月CHAP几乎完全吸收。
CHAP在体内具有良好的组织相容性和骨传导性。CHAP生物降解与骨形成之间存在相应的同步性。CHAP是一种优良的骨缺损修复材料。
