Helou Nancy, Obeid Omar, Azar Sami T, Hwalla Nahla
Department of Nutrition and Food Science, Faculty of Agriculture and Food Sciences, American University of Beirut, Beirut, Lebanon.
Ann Nutr Metab. 2008;52(3):188-95. doi: 10.1159/000138122. Epub 2008 Jun 11.
This study investigated the effect of macronutrient composition of meals on postprandial peptide YY(3-36) (PYY(3-36)) response in obese hyperinsulinemic females.
Eight obese females consumed three iso-energetic meals of different macronutrient composition, high carbohydrate (HC; 60% CHO, 20% protein, 20% fat), high fat (HF; 30% CHO, 20% protein, 50% fat) and high protein (HP; 30% CHO, 50% protein, 20% fat), on three separate occasions, 1 month apart. PYY(3-36), insulin and glucose were measured before and 15, 30, 60, 120 and 180 min following each meal.
PYY(3-36) levels increased significantly following the three meals, with the HC meal resulting in a sustained postprandial increase in PYY(3-36) level throughout the experimental period. Comparing the three meals, the HF meal induced a significantly higher increase in postprandial PYY(3-36) levels, at 15 and 30 min as compared to the HP meal (p < 0.05), whereas the postprandial increase following the HP meal became significantly higher than that following the HF meal at 120 min. Postprandial increase in PYY(3-36) was highest in the first hour following the HF meal, while that following the HP meal was delayed by 1 h.
Increasing both protein and fat content of a meal may induce an immediate and prolonged increase in PYY(3-36), resulting in increased satiety and its maintenance for a longer period of time.
本研究调查了餐食中宏量营养素组成对肥胖高胰岛素血症女性餐后肽YY（3 - 36）[PYY（3 - 36）]反应的影响。
八名肥胖女性在三个不同的时间分别食用了三种宏量营养素组成不同但能量相等的餐食，即高碳水化合物餐（HC；60%碳水化合物，20%蛋白质，20%脂肪）、高脂肪餐（HF；30%碳水化合物，20%蛋白质，50%脂肪）和高蛋白餐（HP；30%碳水化合物，50%蛋白质，20%脂肪），每次间隔1个月。在每餐之前以及餐后15、30、60、120和180分钟测量PYY（3 - 36）、胰岛素和葡萄糖水平。
三餐后PYY（3 - 36）水平均显著升高，HC餐导致整个实验期间餐后PYY（3 - 36）水平持续升高。比较三餐，HF餐在餐后15和30分钟时诱导的餐后PYY（3 - 36）水平升高显著高于HP餐（p < 0.05），而HP餐在餐后120分钟时的餐后升高显著高于HF餐。HF餐后第一小时内PYY（3 - 36）的餐后升高最高，而HP餐的餐后升高延迟了1小时。
增加餐食中的蛋白质和脂肪含量可能会诱导PYY（3 - 36）立即且持续升高，从而导致饱腹感增加并能维持更长时间。
