Grassi Guido, Quarti-Trevano Fosca, Dell'oro Raffaella, Mancia Giuseppe
Clinica Medica, Università Milano-Bicocca Ospedale San Gerardo, Via Pergolesi 33, 20052 Monza, Milan, Italy.
Neurol Sci. 2008 May;29 Suppl 1:S33-6. doi: 10.1007/s10072-008-0882-9.
Sympathetic neural factors exert a key role in homeostatic blood pressure control. Evidence is available that abnormalities in sympathetic function may favour the development and progression of the hypertensive state. This paper will review the data collected throughout the years on the role of adrenergic mechanisms in the pathophysiology of the hypertensive state. It will then examine the mechanisms and the consequences of the sympathetic overdrive reported in hypertension, with particular emphasis on its role in the development of target organ damage. Finally the therapeutic implications of hypertension-related neurogenic abnormalities will be highlighted.
交感神经因素在血压稳态控制中发挥关键作用。有证据表明，交感神经功能异常可能促进高血压状态的发生和发展。本文将回顾多年来收集的关于肾上腺素能机制在高血压状态病理生理学中作用的数据。然后将研究高血压中报道的交感神经过度兴奋的机制和后果，特别强调其在靶器官损伤发展中的作用。最后将突出与高血压相关的神经源性异常的治疗意义。
