Mancia Giuseppe, Grassi Guido
Department of Prevention, Clinica Medica, Ospedale San Gerardo, Monza (Milan), Italy.
Handb Clin Neurol. 2013;117:329-35. doi: 10.1016/B978-0-444-53491-0.00026-2.
The sympathetic nervous system participates in the development and progression of the essential hypertensive state, as shown by increased circulating plasma levels of the adrenergic neurotransmitter norepinephrine, elevated norepinephrine spillover rate, and augmented sympathetic nerve traffic discharge detected in the high blood pressure state. In addition, the sympathetic overdrive participates in the development of the metabolic disarray as well as target organ damage frequently detected in this condition. The above mentioned sympathetic abnormalities explain why adrenergic overdrive represents an important therapeutic target in the treatment of hypertension.
交感神经系统参与原发性高血压状态的发生和发展，这表现为循环血浆中肾上腺素能神经递质去甲肾上腺素水平升高、去甲肾上腺素溢出率升高，以及在高血压状态下检测到的交感神经活动放电增强。此外，交感神经过度兴奋还参与了这种情况下经常出现的代谢紊乱和靶器官损伤的发生。上述交感神经异常解释了为什么肾上腺素能过度兴奋是高血压治疗中的一个重要治疗靶点。
