酪氨酸羟化酶基因变异在高血压发病机制中的作用
Genetic Variations of Tyrosine Hydroxylase in the Pathogenesis of Hypertension.
作者信息
Lee Yu Ho, Kim Yang Gyun, Moon Ju-Young, Kim Jin Sug, Jeong Kyung-Hwan, Lee Tae Won, Ihm Chun-Gyoo, Lee Sang Ho
机构信息
Division of Nephrology, Department of Internal Medicine, Kyung Hee University School of Medicine, Seoul, Korea.
出版信息
Electrolyte Blood Press. 2016 Dec;14(2):21-26. doi: 10.5049/EBP.2016.14.2.21. Epub 2016 Dec 31.
Abstract
One of the major pathophysiological features of primary hypertension is an inappropriate activation of the sympathetic nervous system, which is mediated by excessive synthesis and secretion of catecholamine into the blood. Tyrosine hydroxylase (TH), a rate-limiting enzyme in the synthesis of catecholamine, has been highlighted because genetic variations of could alter the activity of the sympathetic nervous system activity and subsequently contribute to the pathogenesis of hypertension. Here, we discuss the role of TH as a regulator of sympathetic activity and review several studies that investigated the relationship between genetic variations of and hypertension.
摘要
原发性高血压的主要病理生理特征之一是交感神经系统的不适当激活，这是由儿茶酚胺过度合成并分泌入血所介导的。酪氨酸羟化酶（TH）作为儿茶酚胺合成中的限速酶，受到了关注，因为其基因变异可能改变交感神经系统的活性，进而导致高血压的发病机制。在此，我们讨论TH作为交感神经活动调节因子的作用，并综述几项研究，这些研究探讨了其基因变异与高血压之间的关系。
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