Jørgensen B, Gottrup F, Karlsmark T, Bech-Thomsen N, Sibbald R G
Copenhagen Wound Healing Centre, Bispebjerg Hospital, Copenhagen, Denmark.
J Wound Care. 2008 May;17(5):210-4. doi: 10.12968/jowc.2008.17.5.29153.
To investigate the effect and safety of an ibuprofen-releasing foam (Biatain-Ibu, Coloplast A/S) combined with an ionised silver-releasing wound contact layer (Physiotulle Ag, Coloplast A/S) on painful, infected venous leg ulcers.
This open non-comparative study involved 24 patients with painful, exuding, locally infected, and stalled venous leg ulcers. Persistent pain and pain at dressing change were monitored using a 11-point numerical box scale (NBS). The composition of the wound bed, the dressing combination's ability to absorb exudate and minimise leakage, ibuprofen content in the exudate, reduction in wound area and adverse effects were also recorded.
Persistent wound pain decreased from a mean of 6.3 +/- 2.2 to 3.0 +/- 1.7 after 12 hours and remained low thereafter. Pain at dressing change also decreased and remained low. Forty-eight hours after the first dressing application, the mean concentration of ibuprofen in the wound exudate reached a constant level of 35 +/- 21 microg/ml. After 31 days, the relative wound area had reduced by 42%, with an associated decrease in fibrin and an increase in granulation tissue. The number of patients with wound malodour decreased from 37% to 4%. No serious adverse events were reported.
The combined use of the ibuprofen-releasing foam dressing and silver-releasing contact layer reduced wound pain and promoted healing without compromising safety.
探讨布洛芬缓释泡沫敷料（比亚泰因 - 布洛芬，康乐保公司）联合含离子银的伤口接触层（菲丝奥银，康乐保公司）治疗疼痛性感染下肢静脉溃疡的疗效及安全性。
本开放性非对照研究纳入24例有疼痛、渗液、局部感染且愈合停滞的下肢静脉溃疡患者。采用11点数字量表（NBS）监测持续性疼痛及换药时的疼痛情况。记录伤口床的组成、敷料组合吸收渗液及减少渗漏的能力、渗液中的布洛芬含量、伤口面积的缩小情况及不良反应。
持续性伤口疼痛在12小时后从平均6.3±2.2降至3.0±1.7，此后一直维持在较低水平。换药时的疼痛也减轻并维持在低水平。首次换药48小时后，伤口渗液中布洛芬的平均浓度达到35±21微克/毫升的稳定水平。31天后，相对伤口面积缩小了42%，同时纤维蛋白减少，肉芽组织增多。伤口有异味的患者数量从37%降至4%。未报告严重不良事件。
联合使用布洛芬缓释泡沫敷料和含银接触层可减轻伤口疼痛并促进愈合，且不影响安全性。
