Plurad David, Demetriades Demetrios, Gruzinski Ginger, Preston Christy, Chan Linda, Gaspard Donald, Margulies Daniel, Cryer Gill
University of Southern California, Los Angeles, California, USA.
J Emerg Med. 2010 Jan;38(1):12-7. doi: 10.1016/j.jemermed.2007.09.048. Epub 2008 Jun 11.
The effect of alcohol ingestion on short-term outcomes for trauma patients is indeterminate. Experimental and clinical reports often conflict. The objective of this study was to investigate the prevalence of positive alcohol screens, the effect of alcohol ingestion on injury patterns, severity, and outcomes in patients who were involved in motor vehicle crashes (MVC). MVC patients aged > 10 years treated in any of the 13 trauma centers in Los Angeles County during the calendar year 2003 were studied. All patients underwent routine alcohol screening on admission. The alcohol negative group ("no ETOH") had a blood alcohol level (BAL) of < or = 0.005 g/dL. Low and high alcohol groups ("low ETOH" and "high ETOH") had a BAL of > 0.005 g/dL to < 0.08 g/dL and > or = 0.08 g/dL, respectively. Logistic regression was performed to compare injury severity, complications, survival, and length of hospital stay among the three groups. Of the 3025 patients studied, 2013 (67%) were in the no ETOH group, 216 (7%) were in the low ETOH group, and 796 (26%) were in the high ETOH group. Levels were not associated with injury severity, Emergency Department hypotension, or Intensive Care Unit length of stay. Patients with an injury severity score > 15 and a high BAL had a higher incidence of severe head trauma (head abbreviated injury score > 3) and increased incidence of sepsis. However, in this group of severely injured, the high ETOH group had a significantly better survival rate than patients in the no ETOH group (adjusted odds ratio 0.41, 95% confidence interval 0.16-0.94, p = 0.05). Severely injured MVC victims with a high BAL have a higher incidence of severe head trauma and septic complications than no ETOH patients. However, the high ETOH group had superior adjusted survival rates.
酒精摄入对创伤患者短期预后的影响尚无定论。实验和临床报告常常相互矛盾。本研究的目的是调查酒精筛查呈阳性的发生率,以及酒精摄入对机动车碰撞(MVC)患者损伤模式、严重程度和预后的影响。对2003年全年在洛杉矶县13家创伤中心之一接受治疗的年龄大于10岁的MVC患者进行了研究。所有患者入院时均接受常规酒精筛查。酒精阴性组(“无乙醇”)的血液酒精水平(BAL)≤0.005 g/dL。低酒精组和高酒精组(“低乙醇”和“高乙醇”)的BAL分别>0.005 g/dL至<0.08 g/dL和≥0.08 g/dL。进行逻辑回归以比较三组患者的损伤严重程度、并发症、生存率和住院时间。在研究的3025例患者中,2013例(67%)属于无乙醇组,216例(7%)属于低乙醇组,796例(26%)属于高乙醇组。酒精水平与损伤严重程度、急诊科低血压或重症监护病房住院时间无关。损伤严重程度评分>15且BAL高的患者严重颅脑损伤(头部简明损伤评分>3)的发生率较高,脓毒症发生率增加。然而,在这组重伤患者中,高乙醇组的生存率明显高于无乙醇组患者(调整后的优势比为0.41,95%置信区间为0.16 - 0.94,p = 0.05)。BAL高的重伤MVC受害者比无乙醇患者发生严重颅脑损伤和脓毒症并发症的发生率更高。然而,高乙醇组的调整后生存率更高。