Xiao Hang, Yang Chung S
Department of Food Science, University of Massachusetts, Amherst, MA 01003, USA.
Int J Cancer. 2008 Sep 1;123(5):983-90. doi: 10.1002/ijc.23718.
Statins and nonsteroidal antiinflammatory drugs (NSAIDs) are commonly prescribed for lowering cholesterol and anti-inflammation, respectively. Recently, their potential roles as cancer chemopreventive agents have been subject to intensive studies. Human trials have not provided conclusive results on the protective effects of statins against different cancers, while more convincing results have been observed for cancer preventive effects of NSAIDs, especially on colorectal cancer. A promising strategy to enhance the cancer preventive efficacy of statins and NSAIDs is to use them in combination, which may produce synergy and lower the dose required for each agent. This strategy is of particular interest for potential use of low doses of statins and NSAIDs on a long-term basis for cancer chemoprevention; increased risks for gastrointestinal and cardiovascular side effects associated with the use of NSAIDs have been observed in colorectal cancer chemopreventive trials. This article reviews the evidence for the cancer preventive actions of statins and NSAIDs, as well as their possible synergistic action and the mechanisms involved.
他汀类药物和非甾体抗炎药（NSAIDs）通常分别用于降低胆固醇和抗炎。最近，它们作为癌症化学预防剂的潜在作用受到了深入研究。人体试验尚未就他汀类药物对不同癌症的保护作用提供确凿结果，而对于NSAIDs的癌症预防作用，尤其是对结直肠癌的预防作用，已观察到更具说服力的结果。提高他汀类药物和NSAIDs癌症预防功效的一个有前景的策略是联合使用它们，这可能产生协同作用并降低每种药物所需的剂量。这种策略对于长期低剂量使用他汀类药物和NSAIDs进行癌症化学预防的潜在用途尤为重要；在结直肠癌化学预防试验中已观察到与使用NSAIDs相关的胃肠道和心血管副作用风险增加。本文综述了他汀类药物和NSAIDs癌症预防作用的证据，以及它们可能的协同作用和相关机制。
