Brin V B, Tsabolova Z T
Biull Eksp Biol Med. 1991 Feb;111(2):118-20.
The effects of the pig calcitonin on the kidney excretory function in normotensive (NR) and spontaneously hypertensive rats (SHR) were examined. Calcitonin injection in the dose of 0.6 U/100 g of the body mass in NR and SHR in the conditions of 6-hour spontaneous diuresis caused the increase in the urination volume due to the inhibition of the tubular water reabsorption and growth of the glomerular filtration rate. The important role in the mechanism of the decrease in the water reabsorption in SHR plays the decrease in the content of vasopressin in the blood and urea in the kidney interstitium while in NR a more marked inhibition of the water reabsorption is caused by the decrease in the concentration of both urea and sodium in the kidney layers. The natriuretic effect of calcitonin was noticed only in NR.
研究了猪降钙素对正常血压大鼠（NR）和自发性高血压大鼠（SHR）肾脏排泄功能的影响。在6小时自发性利尿条件下，给NR和SHR注射剂量为0.6 U/100 g体重的降钙素，由于肾小管对水的重吸收受到抑制以及肾小球滤过率增加，导致尿量增多。在SHR中，血液中血管加压素含量和肾间质中尿素含量降低在水重吸收减少的机制中起重要作用，而在NR中，肾层中尿素和钠浓度降低导致对水重吸收的抑制更为明显。降钙素的利钠作用仅在NR中观察到。
