Koenders P G, Beex L V, Langens R, Kloppenborg P W, Smals A G, Benraad T J
Department of Medicine, University Hospital Nijmegen, The Netherlands.
Breast Cancer Res Treat. 1991 Mar;18(1):27-32. doi: 10.1007/BF01975440.
A series of 258 breast cancer patients with known estrogen receptor (ER) status of the primary tumour who subsequently developed metastases were reviewed for site of first metastasis. In 188 cases progesterone receptor (PgR) data were also available. Univariate analysis showed metastatic patterns to differ statistically significantly related to ER status and (less pronounced) PgR status of the primary tumour. Patients with ER-positive tumours had bone metastases three times more often than patients with ER-negative tumours. With respect to PgR-positive and PgR-negative tumours this frequency differed by a factor of two. With regard to visceral metastases ER and PgR status were equally potent prognosticators, patients with receptor negative tumours having a 50% higher frequency of visceral metastasis than patients with receptor positive tumours. Assessment of metastatic patterns in relation to combined receptor status did not substantially enhance the discriminatory value of ER and PgR when assessed separately. Multivariate analysis showed that the observed differences in metastatic patterns were all attributable to differences in the ER status of the primary tumour, and were not influenced by age, menopausal status, axillary lymph node involvement, duration of disease-free interval (DFI), mode of postoperative treatment, or the PgR status of the primary tumour.
对258例已知原发性肿瘤雌激素受体（ER）状态且随后发生转移的乳腺癌患者进行回顾，以确定首次转移部位。其中188例患者也有孕激素受体（PgR）数据。单因素分析显示，转移模式与原发性肿瘤的ER状态以及（不太明显的）PgR状态在统计学上有显著差异。ER阳性肿瘤患者发生骨转移的频率是ER阴性肿瘤患者的三倍。对于PgR阳性和PgR阴性肿瘤，这一频率相差两倍。关于内脏转移，ER和PgR状态是同样有效的预后指标，受体阴性肿瘤患者发生内脏转移的频率比受体阳性肿瘤患者高50%。与联合受体状态相关的转移模式评估在单独评估ER和PgR时，并没有显著提高其鉴别价值。多因素分析表明，观察到的转移模式差异均归因于原发性肿瘤ER状态的差异，且不受年龄、绝经状态、腋窝淋巴结受累情况、无病间期（DFI）持续时间、术后治疗方式或原发性肿瘤PgR状态的影响。
