Qazi R, Chuang J L, Drobyski W
Arch Intern Med. 1984 Dec;144(12):2365-7.
To determine if the pattern of relapse in patients with breast cancer was influenced by the presence or absence of hormonal receptors, we examined 300 patients with breast cancer who had estrogen receptor (ER) assays performed on their primary tumors. A multivariate discriminant analysis of the initial site of recurrence was performed, and we included in the analysis such factors as ER status, menopausal status, axillary lymph node involvement, and the interaction between menopausal status and ER status. Estrogen receptor status was found to be the single most important independent variable associated with the pattern of recurrence. There was significantly higher likelihood of visceral metastasis with ER-negative tumors, 52.1% as opposed to 5.38% for ER-positive tumors. Conversely, there was a high frequency of osseous relapse with ER-positive tumors, 60.4%, as opposed to 13.4% for ER-negative tumors. We also found that postmenopausal women tended to be ER positive more often than premenopausal women, and progesterone receptor status appears to be a good indicator for five-year disease-free survival in patients without axillary node involvement. With the progression of disease, there was a loss of receptors, even without therapeutic intervention.
为了确定乳腺癌患者的复发模式是否受激素受体存在与否的影响，我们对300例乳腺癌患者进行了研究，这些患者的原发性肿瘤均进行了雌激素受体（ER）检测。我们对复发的初始部位进行了多变量判别分析，分析中纳入了ER状态、绝经状态、腋窝淋巴结受累情况以及绝经状态与ER状态之间的相互作用等因素。结果发现，雌激素受体状态是与复发模式相关的唯一最重要的独立变量。ER阴性肿瘤发生内脏转移的可能性显著更高，为52.1%，而ER阳性肿瘤为5.38%。相反，ER阳性肿瘤发生骨转移的频率较高，为60.4%，而ER阴性肿瘤为13.4%。我们还发现，绝经后女性ER阳性的情况往往比绝经前女性更常见，并且对于无腋窝淋巴结受累的患者，孕激素受体状态似乎是预测五年无病生存的良好指标。随着疾病进展，即使没有治疗干预，受体也会丢失。
