乳腺癌中的雌激素受体状态与转移部位
Oestrogen-receptor status and sites of metastasis in breast cancer.
作者信息
Campbell F C, Blamey R W, Elston C W, Nicholson R I, Griffiths K, Haybittle J L
出版信息
Br J Cancer. 1981 Sep;44(3):456-9. doi: 10.1038/bjc.1981.205.
Abstract
The oestrogen receptor (RE) status of the primary tumour has been assessed in 466 of a consecutive series of 550 patients with primary operable breast cancer. All patients were followed up (without treatment) until the development of recurrence or metastases. Distant metastases have so far occurred in 124 patients and 82 have had symptomatic local or regional recurrence. A significant correlation exists between the RE status of the primary tumour and subsequent patterns of metastasis. Symptomatic metastases to regional lymph nodes are more common with RE- cancers. There is no significant difference in either time of onset or total incidence of distant metastases between patients with RE+ and RE- tumours. Distribution of distant metastases is influenced by RE status: RE+ tumours tend to recur in bone, RE- tumours show affinity for viscera.
摘要
在连续的550例原发性可手术乳腺癌患者中，对其中466例患者的原发肿瘤雌激素受体（RE）状态进行了评估。所有患者均接受随访（未接受治疗），直至出现复发或转移。到目前为止，124例患者发生了远处转移，82例出现了有症状的局部或区域复发。原发肿瘤的RE状态与随后的转移模式之间存在显著相关性。RE阴性肿瘤患者出现有症状的区域淋巴结转移更为常见。RE阳性和RE阴性肿瘤患者在远处转移的发病时间或总发生率上均无显著差异。远处转移的分布受RE状态影响：RE阳性肿瘤倾向于在骨中复发，RE阴性肿瘤对内脏有亲和性。
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