Silva Afonso C, Bock Nicholas A
Cerebral Microcirculation Unit, Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892-1065, USA.
Schizophr Bull. 2008 Jul;34(4):595-604. doi: 10.1093/schbul/sbn056. Epub 2008 Jun 11.
The metal manganese is a potent magnetic resonance imaging (MRI) contrast agent that is essential in cell biology. Manganese-enhanced magnetic resonance imaging (MEMRI) is providing unique information in an ever-growing number of applications aimed at understanding the anatomy, the integration, and the function of neural circuits both in normal brain physiology as well as in translational models of brain disease. A major drawback to the use of manganese as a contrast agent, however, is its cellular toxicity. Therefore, paramount to the successful application of MEMRI is the ability to deliver Mn2+ to the site of interest using as low a dose as possible while preserving detectability by MRI. In the present work, the different approaches to MEMRI in translational neuroimaging are reviewed and challenges for future identified from a practical standpoint.
金属锰是一种强大的磁共振成像（MRI）造影剂，在细胞生物学中至关重要。锰增强磁共振成像（MEMRI）在越来越多旨在了解正常脑生理学以及脑疾病转化模型中神经回路的解剖结构、整合情况和功能的应用中提供独特信息。然而，将锰用作造影剂的一个主要缺点是其细胞毒性。因此，成功应用MEMRI的关键在于能够以尽可能低的剂量将Mn2+输送到感兴趣的部位，同时保持MRI的可检测性。在本工作中，从实际角度对转化神经成像中MEMRI的不同方法进行了综述，并确定了未来的挑战。
