Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
Laboratory of Viral Immunology and Intravital Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
Neuroimage. 2017 Aug 1;156:146-154. doi: 10.1016/j.neuroimage.2017.05.025. Epub 2017 May 13.
There has been a growing interest in the use of manganese-enhanced MRI (MEMRI) for neuronal tract tracing in mammals, especially in rodents. For this MEMRI application, manganese solutions are usually directly injected into specific brain regions. Recently it was reported that manganese ions can diffuse through intact rat skull. Here the local manganese concentrations in the brain tissue after transcranial manganese application were quantified and the effectiveness of tracing from the area under the skull where delivery occurred was determined. It was established that transcranially applied manganese yields brain tissue enhancement dependent on the location of application on the skull and that manganese that enters the brain transcranially can trace to deeper brain areas.
人们对锰增强磁共振成像（MEMRI）在哺乳动物，特别是啮齿类动物中的神经元追踪应用越来越感兴趣。对于这种 MEMRI 应用，锰溶液通常直接注射到特定的脑区。最近有报道称，锰离子可以穿过完整的大鼠颅骨扩散。本研究定量分析了经颅锰应用后脑组织中的局部锰浓度，并确定了从颅骨下给药区域进行追踪的效果。结果表明，经颅应用的锰会导致脑组织增强，这取决于颅骨上的应用位置，而且经颅进入大脑的锰可以追踪到更深的脑区。
