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Tissue-specific regulation of SIRT1 by calorie restriction.卡路里限制对SIRT1的组织特异性调节。
Genes Dev. 2008 Jul 1;22(13):1753-7. doi: 10.1101/gad.1650608. Epub 2008 Jun 11.
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The role of calorie restriction and SIRT1 in prion-mediated neurodegeneration.热量限制和SIRT1在朊病毒介导的神经退行性变中的作用。
Exp Gerontol. 2008 Dec;43(12):1086-93. doi: 10.1016/j.exger.2008.08.050. Epub 2008 Aug 30.
3
Depot-specific regulation of NAD/SIRTs metabolism identified in adipose tissue of mice in response to high-fat diet feeding or calorie restriction.高脂饮食喂养或热量限制后，在小鼠脂肪组织中鉴定到了 depot 特异性调节 NAD/SIRTs 代谢的作用。
J Nutr Biochem. 2020 Jun;80:108377. doi: 10.1016/j.jnutbio.2020.108377. Epub 2020 Mar 19.
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[Effects of calorie restriction on SIRT1 expression in liver of nonalcoholic fatty liver disease: experiment with rats].[热量限制对非酒精性脂肪性肝病大鼠肝脏中SIRT1表达的影响：实验研究]
Zhonghua Yi Xue Za Zhi. 2007 May 29;87(20):1434-7.
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Sirtuins regulate key aspects of lipid metabolism.沉默调节蛋白调控脂质代谢的关键方面。
Biochim Biophys Acta. 2010 Aug;1804(8):1652-7. doi: 10.1016/j.bbapap.2009.11.021. Epub 2009 Dec 2.
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Calorie restriction--the SIR2 connection.热量限制——与SIR2的联系。
Cell. 2005 Feb 25;120(4):473-82. doi: 10.1016/j.cell.2005.01.029.
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Calorie restriction increases life span: a molecular mechanism.热量限制延长寿命：一种分子机制。
Nutr Rev. 2006 Feb;64(2 Pt 1):89-92. doi: 10.1301/nr.2006.feb.89-92.
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Increase in activity during calorie restriction requires Sirt1.热量限制期间活动量的增加需要Sirt1。
Science. 2005 Dec 9;310(5754):1641. doi: 10.1126/science.1118357.
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SIRT1 and caloric restriction: an insight into possible trade-offs between robustness and frailty.沉默信息调节因子1与热量限制：对强健与虚弱之间可能存在的权衡的洞察。
Curr Opin Clin Nutr Metab Care. 2009 Jul;12(4):350-6. doi: 10.1097/MCO.0b013e32832c932d.
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SIRT1 regulation of insulin-signalling pathways in liver, white adipose tissue and pancreas during fasting or calorie restriction.禁食或热量限制期间，肝脏、白色脂肪组织和胰腺中SIRT1对胰岛素信号通路的调节作用。
Trends Endocrinol Metab. 2007 Apr;18(3):91-2; author reply 93. doi: 10.1016/j.tem.2007.02.008. Epub 2007 Feb 26.
引用本文的文献
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Hepatoprotective Potential of Green Synthesized Nanoparticles from Peel Extract against HFS Diet-Induced NASH in Mice, Integrated with Chemical Profiling and Molecular Modeling.从果皮提取物绿色合成的纳米颗粒对高脂高糖饮食诱导的小鼠非酒精性脂肪性肝炎的肝保护潜力，结合化学剖析和分子建模
ACS Omega. 2025 Aug 11;10(32):36178-36202. doi: 10.1021/acsomega.5c03992. eCollection 2025 Aug 19.
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Mechanisms Underlying Muscle-Related Diseases and Aging: Insights into Pathophysiology and Therapeutic Strategies.肌肉相关疾病与衰老的潜在机制：对病理生理学和治疗策略的见解
Muscles. 2025 Jul 31;4(3):26. doi: 10.3390/muscles4030026.
3
Transcriptomic and metabolomic insights into the synergistic effects of resveratrol and β-hydroxy-β-methylbutyric acid on hepatic function under varying protein diets in Tibetan sheep.转录组学和代谢组学揭示白藜芦醇和β-羟基-β-甲基丁酸在不同蛋白质日粮下对藏羊肝脏功能的协同作用
Front Nutr. 2025 Jul 8;12:1614114. doi: 10.3389/fnut.2025.1614114. eCollection 2025.
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Molecular Mechanisms Underlying Heart Failure and Their Therapeutic Potential.心力衰竭的分子机制及其治疗潜力。
Cells. 2025 Feb 20;14(5):324. doi: 10.3390/cells14050324.
5
Mitochondrial genetics, signalling and stress responses.线粒体遗传学、信号传导与应激反应。
Nat Cell Biol. 2025 Mar;27(3):393-407. doi: 10.1038/s41556-025-01625-w. Epub 2025 Mar 10.
6
Colorectal Cancer: Pathogenesis and Targeted Therapy.结直肠癌：发病机制与靶向治疗
MedComm (2020). 2025 Mar 6;6(3):e70127. doi: 10.1002/mco2.70127. eCollection 2025 Mar.
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Energy metabolism in health and diseases.健康与疾病中的能量代谢。
Signal Transduct Target Ther. 2025 Feb 18;10(1):69. doi: 10.1038/s41392-025-02141-x.
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Dietary Restriction and Lipid Metabolism: Unveiling Pathways to Extended Healthspan.饮食限制与脂质代谢：揭示延长健康寿命的途径
Nutrients. 2024 Dec 23;16(24):4424. doi: 10.3390/nu16244424.
9
NAD Boosting Strategies.NAD增强策略。
Subcell Biochem. 2024;107:63-90. doi: 10.1007/978-3-031-66768-8_4.
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Erythrocyte nicotinamide adenine dinucleotide concentration is enhanced by systematic sports participation.系统性的体育参与可提高红细胞烟酰胺腺嘌呤二核苷酸的浓度。
BMC Sports Sci Med Rehabil. 2024 Oct 15;16(1):216. doi: 10.1186/s13102-024-00999-y.
本文引用的文献
1
Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes.作为治疗2型糖尿病的疗法的SIRT1小分子激活剂。
Nature. 2007 Nov 29;450(7170):712-6. doi: 10.1038/nature06261.
2
SIRT1 deacetylates and positively regulates the nuclear receptor LXR.沉默调节蛋白1使核受体肝X受体去乙酰化并对其起正向调节作用。
Mol Cell. 2007 Oct 12;28(1):91-106. doi: 10.1016/j.molcel.2007.07.032.
3
SIRT1 improves insulin sensitivity under insulin-resistant conditions by repressing PTP1B.在胰岛素抵抗条件下，沉默调节蛋白1（SIRT1）通过抑制蛋白酪氨酸磷酸酶1B（PTP1B）来提高胰岛素敏感性。
Cell Metab. 2007 Oct;6(4):307-19. doi: 10.1016/j.cmet.2007.08.014.
4
Fasting-dependent glucose and lipid metabolic response through hepatic sirtuin 1.通过肝脏沉默调节蛋白1的禁食依赖性葡萄糖和脂质代谢反应。
Proc Natl Acad Sci U S A. 2007 Jul 31;104(31):12861-6. doi: 10.1073/pnas.0702509104. Epub 2007 Jul 23.
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Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha.通过SIRT1/PGC-1α对肌肉线粒体功能和脂肪酸氧化进行代谢控制。
EMBO J. 2007 Apr 4;26(7):1913-23. doi: 10.1038/sj.emboj.7601633. Epub 2007 Mar 8.
6
Calorie restriction increases muscle mitochondrial biogenesis in healthy humans.热量限制可增加健康人的肌肉线粒体生物合成。
PLoS Med. 2007 Mar;4(3):e76. doi: 10.1371/journal.pmed.0040076.
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Lipid metabolism in the liver.肝脏中的脂质代谢。
Z Gastroenterol. 2007 Jan;45(1):35-41. doi: 10.1055/s-2006-927368.
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Metabolic regulation of SIRT1 transcription via a HIC1:CtBP corepressor complex.通过HIC1:CtBP共抑制复合物对SIRT1转录进行代谢调控。
Proc Natl Acad Sci U S A. 2007 Jan 16;104(3):829-33. doi: 10.1073/pnas.0610590104. Epub 2007 Jan 9.
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SIR2: a potential target for calorie restriction mimetics.SIR2：一种卡路里限制模拟物的潜在靶点。
Trends Mol Med. 2007 Feb;13(2):64-71. doi: 10.1016/j.molmed.2006.12.004. Epub 2007 Jan 4.
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Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha.白藜芦醇通过激活SIRT1和PGC-1α改善线粒体功能并预防代谢性疾病。
Cell. 2006 Dec 15;127(6):1109-22. doi: 10.1016/j.cell.2006.11.013. Epub 2006 Nov 16.
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