Lee Chung-Jen, Subeq Yi-Maun, Wang Chih-Hsien, Lee Ru-Ping, Fang Te-Chao, Hsu Bang-Gee
Department of Nursing, Tzu Chi University, Hualien, Taiwan.
Perit Dial Int. 2008 Jun;28 Suppl 3:S196-200.
Serum ghrelin levels are elevated in uremic patients. However, no data are available on the relationship between metabolic syndrome and serum ghrelin levels in peritoneal dialysis (PD) patients.
Metabolic syndrome and its components were defined using diagnostic criteria recommended by the International Diabetes Federation. Fasting serum samples were taken from 30 PD patients. Serum ghrelin levels were measured by using a commercial enzyme-linked immunosorbent assay kit.
Of the 30 PD patients, 53.3% (16/30) had metabolic syndrome. Fasting serum ghrelin corrected inversely with metabolic syndrome among these PDs patients (p = 0.002). By odds ratio (OR) analysis of metabolic syndrome and metabolic syndrome diagnostic criteria, the predictors for metabolic syndrome are fasting glucose [OR: 39.00; 95% confidence interval (CI): 3.80 to 399.85; p < 0.001], triglycerides (OR: 37.50; 95% CI: 3.64 to 386.51; p < 0.001), and waist circumference (OR: 4.20; 95% CI: 1.95 to 9.03; p < 0.001). Univariate linear regression analysis showed that body weight (r = -0.461, p = 0.010), waist circumference (r = -0.390, p = 0.033), and body mass index (r = -0.438, p = 0.016) were negatively correlated with serum ghrelin, and serum high density lipoprotein [HDL (r = 0.626, p < 0.001)] was positively correlated with serum ghrelin. Multivariate forward stepwise linear regression analysis of the significant variables showed that HDL (R(2) change = 0.392; p < 0.001) was the independent predictor of serum ghrelin in PD patients and explained 39.2% of the variance.
These results indicate an inverse association between circulating fasting ghrelin and metabolic syndrome in PD patients. Serum HDL was associated with serum ghrelin among PD patients.
尿毒症患者血清胃饥饿素水平升高。然而，关于腹膜透析（PD）患者代谢综合征与血清胃饥饿素水平之间的关系尚无数据。
采用国际糖尿病联盟推荐的诊断标准定义代谢综合征及其组分。采集30例PD患者的空腹血清样本。使用商用酶联免疫吸附测定试剂盒测量血清胃饥饿素水平。
30例PD患者中，53.3%（16/30）患有代谢综合征。在这些PD患者中，空腹血清胃饥饿素与代谢综合征呈负相关（p = 0.002）。通过对代谢综合征及代谢综合征诊断标准进行比值比（OR）分析，代谢综合征的预测因素为空腹血糖[OR：39.00；95%置信区间（CI）：3.80至399.85；p < 0.001]、甘油三酯（OR：37.50；95% CI：3.64至386.51；p < 0.001）和腰围（OR：4.20；95% CI：1.95至9.03；p < 0.001）。单变量线性回归分析显示，体重（r = -0.461，p = 0.010）、腰围（r = -0.390，p = 0.033）和体重指数（r = -0.438，p = 0.016）与血清胃饥饿素呈负相关，血清高密度脂蛋白[HDL（r = 0.626，p < 0.001）]与血清胃饥饿素呈正相关。对显著变量进行多变量向前逐步线性回归分析显示，HDL（R(2)变化 = 0.392；p < 0.001）是PD患者血清胃饥饿素的独立预测因素，可解释39.2%的变异。
这些结果表明PD患者循环空腹胃饥饿素与代谢综合征之间存在负相关。PD患者血清HDL与血清胃饥饿素相关。
