Division of Nephrology, Buddhist Dalin Tzu Chi General Hospital, Chiayi, Taiwan.
Eur J Intern Med. 2011 Dec;22(6):e105-9. doi: 10.1016/j.ejim.2011.02.015. Epub 2011 Mar 12.
To evaluate the relationship between metabolic syndrome (MetS) and the fasting serum leptin concentration in hemodialysis (HD) patients.
Fasting blood samples were obtained from 101 HD patients. MetS and its components were defined using the diagnostic criteria of the International Diabetes Federation.
Forty-eight patients (47.5%) had MetS. Serum leptin concentrations were positively correlated with MetS (p<0.001). Serum leptin levels correlated with increasing numbers of MetS criteria in HD patients (p=0.001). Univariate linear regression analysis showed that the pre-HD body weight (p<0.001), waist circumference (p<0.001), body mass index (p=0.001), triglycerides (p=0.003), insulin level (p=0.043), and homeostasis model assessment of insulin resistance (p=0.003) positively correlated with serum leptin levels in HD patients and high-density lipoprotein-cholesterol (p=0.016) negatively correlated with serum leptin levels in HD patients. Multivariate forward stepwise linear regression analysis of the significant variables revealed that pre-HD body weight (R(2)=0.175; p<0.001) was the independent predictor of the fasting serum leptin concentration.
Fasting serum leptin levels positively correlated with MetS and the pre-HD body weight could influence serum leptin in HD patients.
评估代谢综合征（MetS）与血液透析（HD）患者空腹血清瘦素浓度之间的关系。
从 101 名 HD 患者中采集空腹血样。使用国际糖尿病联合会的诊断标准定义 MetS 及其成分。
48 名患者（47.5%）患有 MetS。血清瘦素浓度与 MetS 呈正相关（p<0.001）。血清瘦素水平与 HD 患者 MetS 标准数量的增加相关（p=0.001）。单因素线性回归分析显示，HD 患者的预 HD 体重（p<0.001）、腰围（p<0.001）、体重指数（p=0.001）、甘油三酯（p=0.003）、胰岛素水平（p=0.043）和胰岛素抵抗的稳态模型评估（p=0.003）与血清瘦素水平呈正相关，高密度脂蛋白胆固醇（p=0.016）与 HD 患者的血清瘦素水平呈负相关。对有意义变量进行多元逐步线性回归分析表明，预 HD 体重（R(2)=0.175；p<0.001）是空腹血清瘦素浓度的独立预测因子。
空腹血清瘦素水平与 MetS 呈正相关，预 HD 体重可以影响 HD 患者的血清瘦素水平。
