将运动性设计为大肠杆菌中对依赖LuxI/R的群体感应的表型反应。
Engineering motility as a phenotypic response to LuxI/R-dependent quorum sensing in Escherichia coli.
作者信息
Weiss Lucien E, Badalamenti Jonathan P, Weaver Lane J, Tascone Anthony R, Weiss Paul S, Richard Tom L, Cirino Patrick C
出版信息
Biotechnol Bioeng. 2008 Aug 15;100(6):1251-5. doi: 10.1002/bit.21862.
PMID:18553406
Abstract
The repertoire of functional outputs interfaced with the LuxI/LuxR quorum sensing system in engineered Escherichia coli has been expanded to include motility via inducible expression of motB. Appropriate choice of ribosome binding site controlling MotB translation was crucial to achieving control over motility.
摘要
在工程化大肠杆菌中，与LuxI/LuxR群体感应系统相连接的功能性输出指令集已得到扩展，通过诱导表达motB来实现运动性。控制MotB翻译的核糖体结合位点的恰当选择对于实现对运动性的控制至关重要。
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