Oktem Mesut, Ozcimen Emel Ebru, Uckuyu Ayla, Esinler Ibrahim, Pamuk Baris, Bayraktar Nilufer, Kulaksizoglu Sevsen, Zeyneloglu Hulusi B
Department of Obstetrics and Gynecology, Baskent University School of Medicine, Ankara, Turkey.
Fertil Steril. 2009 Jun;91(6):2545-50. doi: 10.1016/j.fertnstert.2008.03.039. Epub 2008 Jun 12.
To determine the level of plasma soluble CD40 ligand (sCD40L) in patients with polycystic ovary syndrome (PCOS).
Prospective study.
Baskent University School of Medicine in Turkey.
PATIENT(S): Thirty-one patients with PCOS and 31 non-PCOS (control) patients.
INTERVENTION(S): Determination of plasma sCD40L and homocysteine levels.
MAIN OUTCOME MEASURE(S): Plasma sCD40L, fasting glucose, fasting insulin, homeostatic model assessment insulin resistance index (HOMA-IR), LH, FSH, E(2), total T, DHEAS, total cholesterol, high- and low-density lipoprotein cholesterol, triglyceride, homocysteine, and high-sensitivity C-reactive protein (hsCRP).
RESULT(S): The mean serum fasting insulin and HOMA-IR levels were significantly higher in the PCOS group. The mean serum homocysteine level was significantly higher in the PCOS group. Despite a trend for higher high-sensitivity C-reactive protein levels in the PCOS group, the difference did not reach statistical significance. The mean plasma sCD40L level in the PCOS group was significantly higher than that in the control group (5.14 +/- 3.65 ng/mL vs. 3.45 +/- 2.64 ng/mL, respectively).
CONCLUSION(S): Polycystic ovary syndrome is associated with elevated levels of sCD40L and homocysteine.
测定多囊卵巢综合征（PCOS）患者血浆可溶性CD40配体（sCD40L）水平。
前瞻性研究。
土耳其巴斯肯大学医学院。
31例PCOS患者和31例非PCOS（对照）患者。
测定血浆sCD40L和同型半胱氨酸水平。
血浆sCD40L、空腹血糖、空腹胰岛素、稳态模型评估胰岛素抵抗指数（HOMA-IR）、促黄体生成素（LH）、促卵泡生成素（FSH）、雌二醇（E₂）、总睾酮（T）、硫酸脱氢表雄酮（DHEAS）、总胆固醇、高密度脂蛋白胆固醇和低密度脂蛋白胆固醇、甘油三酯、同型半胱氨酸以及高敏C反应蛋白（hsCRP）。
PCOS组血清空腹胰岛素和HOMA-IR水平均值显著更高。PCOS组血清同型半胱氨酸水平均值显著更高。尽管PCOS组高敏C反应蛋白水平有升高趋势，但差异未达到统计学意义。PCOS组血浆sCD40L水平均值显著高于对照组（分别为5.14±3.65 ng/mL和3.45±2.64 ng/mL）。
多囊卵巢综合征与sCD40L和同型半胱氨酸水平升高有关。
