Ho C S, Smith M D
Department of Chemical Engineering, State University of New York at Buffalo, Buffalo, New York 14260.
Biotechnol Bioeng. 1986 May;28(5):668-77. doi: 10.1002/bit.260280506.
The effect of dissolved carbon dioxide on the specific growth rate and the penicillin production rate of Penicillium chrysogenum was examined experimentally. The dissolved carbon dioxide was found to inhibit the specific growth rate and the penicillin production rate when the aerated submerged penicillin fermentation was exposed to influent gases of 12.6 and 20% carbon dioxide, respectively. Upon exposure to influent gases of 3 and 5% carbon dioxide, no pronounced metabolic inhibition was noted.
实验研究了溶解二氧化碳对产黄青霉比生长速率和青霉素生产率的影响。当通气深层青霉素发酵分别暴露于二氧化碳含量为12.6%和20%的进气中时，发现溶解二氧化碳会抑制比生长速率和青霉素生产率。当暴露于二氧化碳含量为3%和5%的进气中时，未观察到明显的代谢抑制现象。
