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World J Microbiol Biotechnol. 1994 Mar;10(2):215-20. doi: 10.1007/BF00360891.
During oxytetracycline production by Streptomyces rimosus TM-55 on sweet potato residue in a solid-state column reactor, the moisture content increased by between 2 and 5% (w/w) during incubation, from an initial content of 70 to 73%, and pH initially increased from 6.0 to 7.3, followed by a gradual decrease to 6.2. Appropriate aeration enhanced oxytetracycline production, while mixing only once daily decreased it. The temperatures in the centre and upper layers of each reactor were higher than elsewhere in static non-aerated cultures. The maximum CO2 concentration ranged from 2.9 to 3.2% (v/v) and the minimum O2 concentration was 11.0 to 17.2% (v/v) in static cultures. Under optimal conditions, each gram of dry substrate produced the equivalent potency of 12 mg oxytetracycline.
在固态柱式反应器中，利用甘薯渣生产土霉素时，链霉菌 TM-55 的含水量从初始的 70%到 73%增加了 2%到 5%（w/w），pH 值从 6.0 增加到 7.3，随后逐渐降低到 6.2。适当的通风可促进土霉素的生产，而每天仅搅拌一次则会降低产量。每个反应器中心和上层的温度均高于静态非充气培养物中的其他地方。在静态培养中，最大的 CO2 浓度范围为 2.9%至 3.2%（v/v），最小的 O2 浓度为 11.0%至 17.2%（v/v）。在最佳条件下，每克干基质产生相当于 12 毫克土霉素的效价。
