每次对细菌的两个组成部分进行重新布线。
Rewiring bacteria, two components at a time.
作者信息
Kohanski Michael A, Collins James J
机构信息
Department of Biomedical Engineering, Center for BioDynamics, and Center for Advanced Biotechnology, Boston University, 44 Cummington St., Boston, MA 02215, USA.
出版信息
Cell. 2008 Jun 13;133(6):947-8. doi: 10.1016/j.cell.2008.05.035.
PMID:18555769
Abstract
In this issue, Skerker et al. (2008) present a rational method for rewiring the protein-protein interactions and output responses of prokaryotic two-component signal transduction systems. This work has important implications for understanding the specificity of protein interactions and for designing protein-based synthetic signaling cascades.
摘要
在本期中，斯克尔克等人（2008年）提出了一种合理的方法，用于重新连接原核双组分信号转导系统的蛋白质-蛋白质相互作用和输出响应。这项工作对于理解蛋白质相互作用的特异性以及设计基于蛋白质的合成信号级联具有重要意义。
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