Sebetan I M
Department of Laboratory Medicine and Pathology, Hamad General Hospital, Doha, Qatar.
Hum Hered. 1991;41(2):138-40. doi: 10.1159/000153991.
The genetic polymorphism of human plasminogen (PLG) was investigated in Libyans using wide-scale ultrathin-layer polyacrylamide isoelectric focusing with subsequent immunoblotting. The 2 common alleles, PLGA and PLGB, and 4 previously reported rare ones, PLGA3, PLGM4, PLGB1 and PLGB2, were observed. In addition, a new intermediate rare allele designated PLGMTripoli (PLGMT) was encountered. The estimated allele frequencies for the genes PLGA, PLGB, PLGA3, PLGMT, PLGM4, PLGB1 and PLG*B2 were 0.6409, 0.3091, 0.0182, 0.0045, 0.0091, 0.0045 and 0.0136, respectively. The isolated probability of exclusion in cases of disputed paternity among Libyans is 23.3%.
利用大规模超薄层聚丙烯酰胺等电聚焦及后续免疫印迹技术，对利比亚人群的人纤溶酶原（PLG）基因多态性进行了研究。观察到2个常见等位基因PLGA和PLGB，以及4个先前报道的罕见等位基因PLGA3、PLGM4、PLGB1和PLGB2。此外，还发现了一个新的中间罕见等位基因，命名为PLG的黎波里（PLGMT）。基因PLGA、PLGB、PLGA3、PLGMT、PLGM4、PLGB1和PLG*B2的估计等位基因频率分别为0.6409、0.3091、0.0182、0.0045、0.0091、0.0045和0.0136。利比亚人亲子关系有争议案件中的排除概率为23.3%。
