Skoda U, Bertrams J, Dykes D, Eiberg H, Hobart M, Hummel K, Kühnl P, Mauff G, Nakamura S, Nishimukai H
Vox Sang. 1986;51(3):244-8. doi: 10.1111/j.1423-0410.1986.tb01963.x.
Since its discovery, human plasminogen (PLG) polymorphism has received widespread acceptance in population genetics and forensic haematology. Due to the large number of variant alleles described, a PLG reference typing and Plasminogen Symposium was held, at which a nomenclature proposal was inaugurated. The technology of comparing PLG variants was based on isoelectric focusing and subsequent detection by caseinolytic overlay and 'Western' blotting. Typing results permitted comparison of so far described variant designations and resulted in a new nomenclature proposal for PLG polymorphism. It is recommended that the two most common alleles found in all investigated races be called: PLGA (previously also PLG1) and PLGB (previously also PLG2), the known variants with acidic pI: PLGA1 to A3, intermediate variants: PLGM1 to M5, PLGM5 being functionally inactive, and basic variants: PLGB1 to *B3. For future classification of newly discovered variants, samples should be compared at any of the laboratories participating in the reference typing.
自发现以来，人纤溶酶原（PLG）多态性在群体遗传学和法医血液学中已被广泛接受。由于已描述的变异等位基因数量众多，因此举办了一次PLG参考分型和纤溶酶原研讨会，会上启动了一项命名提案。比较PLG变异体的技术基于等电聚焦，随后通过酪蛋白溶解覆盖和“Western”印迹法进行检测。分型结果允许对迄今为止描述的变异命名进行比较，并产生了一项关于PLG多态性的新命名提案。建议将在所有调查种族中发现的两种最常见等位基因称为：PLGA（以前也称为PLG1）和PLGB（以前也称为PLG2），已知具有酸性pI的变异体：PLGA1至A3，中间变异体：PLGM1至M5，PLGM5功能失活，以及碱性变异体：PLGB1至*B3。为了对新发现的变异体进行未来分类，应在参与参考分型的任何实验室对样本进行比较。
