Ahmed Faruque, Perz Joseph F, Kwong Sandy, Jamison Patricia M, Friedman Carol, Bell Beth P
Centers for Disease Control and Prevention, 1600 Clifton Rd, MS E-52, Atlanta, GA 30333, USA.
Prev Chronic Dis. 2008 Jul;5(3):A74. Epub 2008 Jun 15.
Previous studies indicate that the incidence of hepatocellular carcinoma in the United States is increasing. These reports, however, have contained limited information on population groups other than whites and blacks.
We assessed recent incidence rates and trends for hepatocellular carcinoma by using newly available national data from cancer registries participating in the Centers for Disease Control and Prevention's National Program of Cancer Registries and the National Cancer Institute's Surveillance, Epidemiology, and End Results Program. Data from registries in 38 states and the District of Columbia met our criteria; these data covered 83% of the U.S. population. We computed age-adjusted incidence rates and annual percentages of change from 1998 through 2003.
The registries that we used reported 48,048 cases of hepatocellular carcinoma (3.4 cases per 100,000 population per year) for the study period. Whites accounted for three-fourths of cases. The incidence rate for blacks was 1.7 times higher than that for whites, and the rate for Asians/Pacific Islanders was 4 times higher than that for whites. Hispanics had 2.5 times the risk of non-Hispanics. Among Asian/Pacific Islander subgroups, rates were highest for people of Vietnamese and Korean origin. For all races/ethnicities combined, the annual percentages of change were 4.8% for males and 4.3% for females (P < .05). The annual percentage of change was highest for people aged 45-59 years (9.0%, P < .05). The annual percentage of change for Asians/Pacific Islanders was statistically unchanged.
We document rising incidence rates of hepatocellular carcinoma in the United States during a time when the overall incidence of cancer has stabilized. Efforts to collect representative etiologic data on new hepatocellular carcinoma cases are needed to enable better characterization of trends and to guide the planning and evaluation of prevention programs.
先前的研究表明，美国肝细胞癌的发病率正在上升。然而，这些报告中关于白人和黑人以外人群的信息有限。
我们利用参与疾病控制和预防中心国家癌症登记计划以及国家癌症研究所监测、流行病学和最终结果计划的癌症登记处新获得的全国数据，评估了肝细胞癌的近期发病率和趋势。来自38个州和哥伦比亚特区登记处的数据符合我们的标准；这些数据覆盖了美国83%的人口。我们计算了1998年至2003年的年龄调整发病率和年变化百分比。
在研究期间，我们使用的登记处报告了48048例肝细胞癌病例（每年每10万人中有3.4例）。白人占病例的四分之三。黑人的发病率比白人高1.7倍，亚洲人/太平洋岛民的发病率比白人高4倍。西班牙裔患癌风险是非西班牙裔的2.5倍。在亚洲/太平洋岛民亚组中，越南裔和韩裔的发病率最高。对于所有种族/族裔群体而言，男性的年变化百分比为4.8%，女性为4.3%（P < 0.05）。45至59岁人群的年变化百分比最高（9.0%，P < 0.05）。亚洲人/太平洋岛民的年变化百分比在统计学上没有变化。
我们记录了在美国癌症总体发病率稳定时期肝细胞癌发病率的上升。需要努力收集关于新肝细胞癌病例的代表性病因数据，以便更好地描述趋势并指导预防计划的规划和评估。
