Servettaz Amélie, Guilpain Philippe, Tamas Nicolas, Kaveri Srini V, Camoin Luc, Mouthon Luc
Université Paris Descartes, Faculté de Médecine, UPRES-EA 4058, Paris, France.
Autoimmun Rev. 2008 Jun;7(6):426-30. doi: 10.1016/j.autrev.2008.03.010. Epub 2008 Apr 8.
Anti-endothelial cell antibodies (AECA) are detectable in a heterogenous group of autoimmune and inflammatory conditions. These antibodies have also been detected in healthy individuals. Nevertheless, most of the literature focuses on AECA in pathological conditions and their targets and functions in healthy individuals remain to be clarified. Recently, proteome-based technologies have been successfully used for the identification of antigens targeted by natural AECA. Thus, it has been shown that IgG AECA can be detected in sera from healthy individuals that recognize a restricted set of proteins among a whole protein extract of umbilical vein endothelial cells. These proteins correspond to ubiquitous proteins belonging to highly conserved protein families and exerting pivotal roles in cell physiology, including cytoskeletal proteins (beta actin, vimentin, alpha tubulin) and glycolytic enzymes (glyceraldehyde-3-phosphate-deshydrogenase and alpha-enolase). As reported for other types of natural autoantibodies, natural AECA could exert anti-inflammatory and anti-thrombotic functions. In addition, they could play a role in the control of EC activation.
抗内皮细胞抗体（AECA）在一组异质性的自身免疫性和炎症性疾病中可被检测到。这些抗体在健康个体中也有发现。然而，大多数文献关注的是病理状态下的AECA，其在健康个体中的靶标和功能仍有待阐明。最近，基于蛋白质组学的技术已成功用于鉴定天然AECA靶向的抗原。因此，已表明在健康个体的血清中可检测到IgG AECA，其能识别脐静脉内皮细胞全蛋白提取物中的一组有限蛋白质。这些蛋白质对应于属于高度保守蛋白家族的普遍存在的蛋白质，并在细胞生理学中发挥关键作用，包括细胞骨架蛋白（β-肌动蛋白、波形蛋白、α-微管蛋白）和糖酵解酶（甘油醛-3-磷酸脱氢酶和α-烯醇化酶）。正如其他类型天然自身抗体的报道，天然AECA可能发挥抗炎和抗血栓形成功能。此外，它们可能在控制内皮细胞激活中发挥作用。
