身体活跃的老年人接种流感病毒疫苗后自身抗体和特异性抗体产量增加。
Increased production of autoantibodies and specific antibodies in response to influenza virus vaccination in physically active older individuals.
作者信息
Bachi André L L, Suguri Vinicius M, Ramos Luiz Roberto, Mariano Mario, Vaisberg Mauro, Lopes Jose D
机构信息
Department of Microbiology and Immunology, Federal University of São Paulo, Brazil.
Department of Otorhinolaryngology, Federal University of São Paulo, Brazil.
出版信息
Results Immunol. 2013 Feb 4;3:10-6. doi: 10.1016/j.rinim.2013.01.001. eCollection 2013.
Abstract
Immunosenescence is associated to aging and among many changes in immune response is reported a reduced response to vaccination and an increase in the number of cases of autoimmunity, caused by autoantibodies known as natural antibodies whose function, according to reports, would be protection against infection and inflammation. Although immunosenescence is an irreversible process, regular moderate exercise can attenuate some aspects of the decline in the immune system. So, the aim of this study was to investigate the humoral immune response in physically active elderly individuals before and 30 days after vaccination against influenza virus. The results showed that the percentage of individuals positive for antinuclear antibodies and serum immunoglobulin M and G levels after vaccination were higher in the group that exercised regularly than in the sedentary group. We were also able to demonstrate a significant correlation between levels of natural autoantibodies and response to vaccination.
摘要
免疫衰老与衰老相关，在免疫反应的诸多变化中，据报道对疫苗接种的反应降低以及自身免疫病例数增加，自身免疫是由被称为天然抗体的自身抗体引起的，据报道其功能是预防感染和炎症。尽管免疫衰老是一个不可逆的过程，但定期适度运动可以减轻免疫系统衰退的某些方面。因此，本研究的目的是调查身体活跃的老年人在接种流感病毒疫苗前和接种后30天的体液免疫反应。结果显示，定期锻炼组接种疫苗后抗核抗体阳性个体的百分比以及血清免疫球蛋白M和G水平高于久坐组。我们还能够证明天然自身抗体水平与疫苗接种反应之间存在显著相关性。
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